Take the Warts tour · 2 stops

The warts clinic · therapy guide

Warts: the full therapy pathway

Walk the pathway

The pharmacy treatment for warts genuinely works, and its own label sets the course at twelve weeks. Almost nobody gets past three. Here is the ramp built around that single fact, the honest clearance figures, and the clinic tier that starts where a finished course ends.

  • 5 stops over the counter
  • 12 weeks then an honest check
  • Up to 3 stops with a prescription
WARTS CLINIC

Education, not medical advice. This page explains how warts is generally treated and why the steps come in this order. It diagnoses nothing and recommends no therapy to anyone. Full disclaimer

Pick the pattern that matches

The over-the-counter start is shared; what happens after the clinic door depends on the pattern. Not sure? Start with the first; the route can be changed at any point.

Walking the route forCommon warts on hands, fingers and elsewhere (verruca vulgaris)
MY PLACEMARKETKEEP GOINGSTEP BACKCLINICWARTS CLINICCLINICCLINICCLINICOVER THE COUNTERPRESCRIPTION← SHELF ENDSPRESCRIPTION →1Before the first purchase2Week 03Weeks 1-44Weeks 5-125Throughout12-week checkClinic door7In-clinic8In-clinic9SpecialistStaying clear

Over the counter

1

Over the counterBefore the first purchase

Confirm it is a wart, and one this counter may treat

Separate a wart from the several harmless and one or two serious things that resemble one.

Morning

  1. Match the growth against the description

    A common wart is firm, raised and rough, with a cauliflower surface, usually on a hand, finger or knee. A verruca on the sole is flatter, ringed by callus, tender squeezed from the sides rather than pressed from above, and interrupts the skin lines that run across the foot. Both usually show tiny dark points once the surface layer is filed back — clotted capillaries, and the single most useful confirming sign available without a clinic.

  2. Check the growth is not behaving oddly

    Bleeding without injury, an eroded or ulcerated centre, steady enlargement over weeks, or a solitary rough patch appearing on sun-damaged skin in an older adult are all reasons to have it examined before treating it. The mimics that matter are not the harmless ones.

Evening

  1. Read the exclusions on the pack before buying it

    Every wart-remover label carries the same list: not on the face or mucous membranes, not on genital warts, not on moles or birthmarks, not on warts with hairs growing from them, and not at all where there is diabetes or poor blood circulation. Each of those is on the label because of a specific harm, and a growth in any of those categories leaves this pathway here.

    Browse all salicylic acid products →

Does the growth match the description, on skin the label permits treating?

Yes — a wart, on hand, foot, knee or elbowGo to step 1 below and set the routine up before starting the clock.

It is on the face, in the genital area, or behaving oddlyThis route ends here. A facial or flat presentation belongs on the branch for it above; anything bleeding, ulcerating or enlarging belongs with a clinician before any treatment starts.

Why this step

Two entirely different mistakes are prevented at this step, and they cost the same thing. Treating a seborrhoeic keratosis or a corn as a wart wastes a season; treating a squamous cell carcinoma as a wart wastes considerably more than that.

Four things that matter more than which pack goes into the basket
  1. 1 · Good to know The course is twelve weeks of near-daily application.

    That number comes off the label of the product itself, not from an opinion held here.

  2. 2 · Good to know Filing the softened white layer back between applications is half the treatment; acid left to build a crust ends up treating the crust.
  3. 3 · Good to know Nothing in this aisle goes on the face, on genital skin, on moles or birthmarks, on hair-bearing warts, or on a foot with diabetes, neuropathy or poor circulation.
  4. 4 · Good to know One file per wart, thrown away afterwards, never returned to shared kit — this virus spreads by contact, including from one part of a person to another.
2

Over the counterWeek 0

Build the routine before starting the clock

Make a twelve-week ritual survivable by making it short.

Morning

  1. Pick the format the site can actually keep

    A collodion liquid suits an awkward wart on a finger where a plaster will not sit. A 40% plaster suits a sole, where it survives a sock and holds contact through a working day. The clinical difference between them is small; the adherence difference is not, and adherence is the variable that decides this.

    Browse all salicylic acid products →

Evening

  1. Assemble the whole kit in one place

    The preparation, a disposable emery board reserved for this wart alone, waterproof tape, and something to protect the ring of skin around the growth — petroleum jelly applied to the margin, or a plaster with a hole cut to the size of the wart.

    Browse all moisturizers →
  2. Fix the routine to something that already happens

    Attaching the application to an existing nightly habit is not a productivity flourish; it is the difference between a twelve-week course and a three-week one, and it is the single highest-yield decision on this page.

Is the kit assembled and the daily slot chosen?

Yes, bothGo to step 2 and start counting from the first application.

Not yetWorth finishing before starting. A course begun without the filing kit becomes an acid-only course, which is a weaker version of the treatment that has to run just as long.

Why this step

Every trial that produced the clearance figures quoted above tested a regimen with soaking, filing and daily application built into it. A course missing those components is not the treatment those trials measured.

3

Over the counterWeeks 1-4

Weeks 1 to 4: apply, file, and expect nothing

Establish the habit and correctly interpret an absence of results.

Morning

  1. File back the softened white layer

    Softened tissue only, and stopping well before anything pink or tender. Filing until it bleeds does not remove the wart faster; it opens fresh skin for the virus to move into and is one of the ways a single wart becomes several.

Evening

  1. Soak, dry, apply, cover

    A few minutes in warm water, dried thoroughly, the preparation applied only to the wart itself with the surrounding margin protected, then covered. Liquids are applied daily; high-strength plasters are usually changed every couple of days as the pack directs.

    Browse all salicylic acid products →

Has the routine actually run on most days this month?

Yes, most daysGo to step 3. The part that decides the outcome is the part that comes next.

It has been patchyRestart the count from today rather than abandoning it. A patchy month is not a failed course, but it is not a month of the course either, and the twelve weeks measure applications rather than calendar time.

Why this step

This month is where the failure mode lives. The wart is expected to look unchanged, because the acid is working through dead tissue that has to be removed layer by layer before anything living is reached. An unchanged wart at week four is a course running normally, not a product that does not work.

4

Over the counterWeeks 5-12

Weeks 5 to 12: the stretch where courses are abandoned

Reach a real verdict instead of an imagined one.

Morning

  1. Keep filing, and watch the surface rather than the size

    A wart that is answering loses its texture before it loses its bulk: the cauliflower roughness flattens, the dark points thin out, and the skin lines that the wart interrupted start to reappear at the edges. Size is the last thing to change and the first thing people measure.

Evening

  1. Continue the nightly application without interruption

    Interruptions of more than a few days let the softened layer reharden, which effectively returns the course to an earlier week. Where the surrounding skin becomes sore, the answer is better margin protection and a night off, not abandonment.

    Browse all salicylic acid products →
  2. Photograph the site once a fortnight

    Change at this speed is invisible to daily inspection and is reliably underestimated from memory. A photograph in the same light every two weeks is the only honest record of whether anything is happening.

Have twelve weeks of applications actually accumulated?

Yes — twelve applied weeksGo to the checkpoint below. Whatever the answer is now, it is a real one.

Not yetThen the checkpoint is not due. Continuing to the twelfth week costs a few more minutes a night and is the only thing that makes the next tier's decision an informed one.

Why this step

Nearly every account of a wart treatment failing describes a course that ended between weeks three and five. The trials that found salicylic acid clearing around half of warts ran their treatment arms for six to twelve weeks, so a course stopped in week four has not produced a result that can be compared with anything.

5

Over the counterThroughout

Stop it spreading while the course runs

Keep one wart from becoming several while the first is treated.

Morning

  1. Keep the wart covered in shared spaces

    A plaster over the site for swimming, communal showers and changing rooms, and footwear rather than bare feet on wet floors. The virus is picked up and passed on where skin is soft and floors are shared.

Evening

  1. Break the picking and biting habit

    Warts spread into any break in nearby skin, which is why bitten fingers grow rows of them around the nail folds and shaved skin grows them along a razor line. Covering the wart is the practical intervention, and it works better than instructions not to touch it.

    Browse all moisturizers →
  2. Keep the tools out of circulation

    Files, pumice, clippers and towels used on a wart do not go back into shared kit or a salon bag. This is the most frequent route by which one household member's verruca becomes two.

Is the wart covered in shared spaces and are the tools kept separate?

YesThat is the containment side complete; it continues until the site has fully healed.

Not consistentlyWorth fixing now rather than later — new warts appearing during a course are usually spread rather than treatment failure, and they reset the clock on the whole episode.

Why this step

Spread by self-inoculation is what turns a twelve-week problem into a two-year one, and it happens through ordinary handling rather than anything unusual. This step runs alongside every other one rather than after them.

Checkpoint12 weeks on the full routine

The twelve-week verdict

By surface, not size. A wart that is clearing loses its rough texture first, then its dark points, and the skin lines that ran into it and stopped begin to run through it. Flat skin with continuous lines is cure; a smaller but still rough lump is partial and worth continuing.

After twelve applied weeks, what does the skin actually show?

Gone — skin lines run through“Gone — skin lines run through”Cured, with a fortnight of confirming still worth doing.

Continuing to protect the site for another two weeks costs little and matters more than it sounds: recurrence tends to happen at the site that just healed, and the virus can persist in skin that looks entirely normal. Keeping the area covered in shared spaces and keeping the tools separate is the whole of the aftercare.

Smaller, flatter, fewer dark points“Smaller, flatter, fewer dark points”Answering — the course extends rather than escalates.

A wart that has visibly flattened at twelve weeks is on its way, and stopping now is the most avoidable mistake left on this page. Continuing for a further four to eight weeks on the same routine is standard practice, and there is no separate benefit to switching product mid-response.

No change after twelve applied weeks“No change after twelve applied weeks”The over-the-counter tier is finished here.

Around half of completed courses end this way, which makes this the expected result rather than a disappointing one, and it is the moment this pathway was built to reach honestly. A completed course is also the strongest thing to carry into an appointment: the clinician is no longer being asked to guess whether the cheapest option would have worked, because that question has already been answered.

Step back“Painful, raw, or the surrounding skin is damaged”Stop, rather than escalate.

Sore, weeping or broken skin around the wart means the acid has reached tissue it was never meant to, and continuing makes both the wound and the spread risk worse. Stopping, letting the skin heal, and protecting the margin more carefully next time is the correct response; a spreading redness, increasing pain or discharge needs looking at rather than waiting.

The applications did not really happen“The applications did not really happen”An untried course, not a failed one.

This is the commonest honest answer at week twelve and it deserves saying plainly, because the alternative is that a working treatment gets recorded as a failure and the next tier starts from a false premise. A course that ran for three weeks has produced no evidence about anything. Restarting with the routine attached to a fixed daily habit is a better use of the next three months than moving up a tier that has its own costs.

The clinic doorWhere the shelf ends

Where the over-the-counter pathway ends

On the shelfAvailable without seeing anyone
Behind the doorPrescribed, matched by examination, sometimes monitored

It ends at a completed course, which is a specific and deliberately narrow definition: twelve weeks of applications that actually took place, with filing between them. Everything above this line is available in a supermarket for the price of a sandwich, has better trial support than most of what surrounds it on the shelf, and finished level with professional freezing in the trials that compared them directly. What lies past it is not stronger chemistry so much as more force, more supervision and more cost — and the case for accepting those is built entirely on the course below having been finished first.

With a prescription

In-office procedurePrescription step 1

Clinic destruction, on a two-to-three-week rhythm

The clinic tier does the same job with more force and a limit on how many attempts are worth making. Two approaches sit level here rather than in order, and the pooled evidence adds one useful instruction: continuing the acid at home between sessions outperforms either method used alone.

The therapies at this stop

  1. A fair trial

    Three to four sessions at the stated interval, with acid continued at home in between, before the approach is judged.

  2. Working looks like

    The wart shrinking session by session, its surface flattening and its dark points thinning out, with normal skin lines advancing in from the edges.

  3. Next stop if

    A defined course of sessions has ended with the wart substantially unchanged, or new warts continue to appear around the treated one.

In-office procedurePrescription step 2

Blistering and removal, for a single stubborn wart

A wart that has survived a completed course and a course of freezing has demonstrated something about itself, and the options here treat it accordingly. Both carry costs the tiers below do not: a blistering agent can seed a ring of new warts around the site, and surgical removal exchanges a temporary growth for a permanent scar that on a weight-bearing surface may outlast the original complaint.

The therapies at this stop

  1. A fair trial

    A single application or procedure, with healing complete, before anything further is decided — typically three to four weeks.

  2. Working looks like

    The wart lifting away with the blister roof, or the surgical site healing flat with normal skin lines re-established across it.

  3. Next stop if

    The wart returns in or around the treated site, or the count of warts is rising rather than falling.

Specialist carePrescription step 3

Resistant and multiple warts: the specialist tier

At this point the strategy inverts. Destroying warts individually has been tried and has not held, so the tier reaches instead for treatments that act on all of them at once — by making the immune system notice an infection it has been tolerating, or by acting systemically. This is also where availability stops being uniform: what a clinic can offer here depends on its compounding access, its equipment and its country.

The therapies at this stop

In-office procedurePrescription step 1

Clinic treatment, with the acid continued at home

On the sole the clinic tier is a smaller step up than it is on a hand, and the evidence says so: freezing did not beat acid on plantar warts in either of the large primary-care trials, and applied acid in the surgery matched freezing-plus-acid with less pain during treatment. What does have specific plantar support is technique — a second freeze after thawing improved plantar clearance in a way it did not for hand warts.

The therapies at this stop

  1. A fair trial

    A defined course of three to four sessions at two-to-three-week intervals, with home treatment continuing throughout.

  2. Working looks like

    The plaque shrinking from its edges, pressure pain easing, and the callus rebuilding more slowly between visits.

  3. Next stop if

    The defined course has finished without meaningful change, or walking remains painful enough to limit ordinary activity.

Specialist carePrescription step 2

Mosaic and resistant plantar warts

Mosaic verrucas are the hardest form this condition takes, and the specialist tier approaches them knowing that. Injected treatments have the best network-analysis showing for plantar warts specifically, light-based options exist where a service is equipped, and surgery is present but placed last on purpose — a scar on a weight-bearing sole is a durable problem, and this tier is where the decision to accept one is actually made.

The therapies at this stop

Prescription topicalPrescription step 1

Prescription creams chosen for thin skin and high numbers

Where there are twenty flat warts on a face, destroying them one at a time is neither practical nor wise, so the first prescription move treats the whole area at once with something the skin can survive. Retinoids and immune modulators both work slowly and both produce visible inflammation while they do it, which is worth knowing before starting rather than discovering in week two.

The therapies at this stop

  1. A fair trial

    Two to three months of the schedule a prescriber sets, since these agents work gradually and the inflammation they cause is not itself the result.

  2. Working looks like

    The bumps flattening into the surrounding skin and the affected area losing its faint texture, usually across the whole region rather than lesion by lesion.

  3. Next stop if

    A full course has passed with no flattening, or the inflammation has become more troubling than the warts were.

In-office procedurePrescription step 2

Careful, low-energy destruction in a specialist setting

Destruction is possible on a face, but only at settings and depths chosen for it, which is why this rung belongs to dermatology rather than to a general clinic. The governing concern is not clearance but what is left behind: gentle freezing, light chemical treatment and light-based options are all capable of trading a barely visible flat wart for a permanently pale mark, and that risk is higher in richly pigmented skin.

The therapies at this stop

Staying clearThe end of the road

After a wart clears, and why the next few weeks matter

Clearance is confirmed by skin lines running unbroken through the site, not by the lump being gone. Recurrence in the following months is common because the virus can persist in skin that looks entirely normal, and the site most likely to produce the next wart is the one that just healed. Keeping the area covered while it settles, keeping files and clippers out of shared kit, and treating a returning roughness early rather than watching it for a month are what convert a cleared wart into a finished episode.

What holds the line

Coming back

This page is written to be returned to at week twelve rather than read once. The checkpoint above is the moment it was built for, and the honest answer at that point — cleared, answering, unchanged, or never really applied — routes to four genuinely different next steps. The site's photo tracker is built for exactly this kind of slow change, and the questions library carries the smaller queries that arise mid-course without needing an appointment.

Staying clearThe end of the road

Keeping a cleared sole clear

Verrucas are picked up where feet are bare and floors are wet, and the same environments that produced one produce the next. Footwear in communal showers and around pools, a plaster over any healing site while swimming, and drying between the toes are the whole of the prevention story, and they are worth continuing for months after the skin looks normal rather than stopping the week it does.

What holds the line

Coming back

This page is written to be returned to at week twelve rather than read once. The checkpoint above is the moment it was built for, and the honest answer at that point — cleared, answering, unchanged, or never really applied — routes to four genuinely different next steps. The site's photo tracker is built for exactly this kind of slow change, and the questions library carries the smaller queries that arise mid-course without needing an appointment.

Through the clinic door Seeing a dermatologist Pack the bag, pick the questions, know the cost, then build the visit sheet.

General practice is the right first door for almost everything on this page, and in several countries a pharmacist or podiatrist can settle the identity question before an appointment is needed at all. Primary care confirms what the growth is, delivers or arranges freezing and applied acid, and manages the foot warts that should never be treated at home. Podiatry is the parallel route for verrucas, particularly where callus reduction is part of the job or the foot carries risk. Dermatology referral fits a narrower set: diagnostic uncertainty, warts that have survived a completed course and a course of clinic treatment, high numbers, and anything in the immunosuppressed group.

  1. 1

    Pack the bag

    What turns a fifteen-minute appointment into a useful one.

    0 of 5 packed

  2. 2

    The questions to ask

    Tap the ones worth taking in. They collect below, ready to copy or print.

  3. 3

    Cost, and who to see

    The economics run the right way round here for once, and it is worth saying so: the best-evidenced option is the cheapest thing in the aisle, and it is the one people abandon. Clinic freezing is inexpensive or free in publicly funded systems though not always offered for warts, since they are frequently classed as a self-limiting cosmetic problem. Applied acid in a surgery costs little where it is available. The expensive end is entirely private — laser and photodynamic sessions are priced per visit and rarely funded, which makes cost, rather than clinical suitability, the usual reason that tier is or is not reached.

    One thing is worth raising early in a general practice appointment, because it saves an argument: many health systems do not routinely fund wart treatment, on the grounds that warts resolve on their own. That position is defensible on the evidence and infuriating when a verruca has made walking painful for a year. Naming the functional problem — pain, spread, occupational impact — rather than the wart itself is what usually distinguishes the two conversations.

    The route to a clinician differs by country, and for this condition the first door is rarely a dermatologist — primary care, pharmacy and podiatry cover most of the map, with specialist referral reserved for the resistant end.

From the Workshop · free, private, printable Derm Visit Prep: the whole visit on one sheet The appointment that follows a completed course runs on three facts: what was applied, at what strength, and for how many actual days. Those are precisely the details memory supplies worst in a consulting room, and writing them down in advance changes what the visit can decide. Build the sheet
Ask the clinic Common questions 7 answered here. Pick one and the clinic answers.

How long does a wart last if nothing is done about it?

Longer than most people expect and shorter than they fear. In a prospective cohort of primary schoolchildren, half were free of their warts within a year with no treatment, and younger children cleared faster. Adults are generally slower, and warts that have already lasted a year or more tend to keep going. That is why an untroubling wart in a child is a reasonable candidate for watching, and a painful verruca in an adult that has outlasted a year is not.

Pinned in the Square Things people arrive asking about 7 popular remedies, each stamped with how good its evidence really is.

Warts attract folk remedies more than almost any other skin condition, partly because they resolve on their own often enough to make anything applied beforehand look effective. Placed honestly here rather than dismissed, since several are harmless and one or two have real trial data.

Side roads

Warts on immunosuppressed skinManaged alongside the existing specialist team rather than independently of it

Transplant recipients, people on immunosuppressive or biologic medication, and people with immune conditions do not have a more severe version of this condition — they have a different one. Clearance normally depends on immune recognition, and where that is deliberately dampened the arithmetic behind every tier above changes. This is a map of considerations rather than a ladder, because the sequence belongs to the team already managing the underlying situation.

  • 1 Numerous or rapidly multiplying warts

    High numbers push treatment away from destroying lesions individually and toward approaches that act across all of them. Systemic retinoid therapy, rarely justified for warts otherwise, is used in this group precisely because the alternative is an endless queue of individual procedures.

    Matched with

  • 2 A single wart that has resisted everything, or looks unusual

    The association between long-standing viral warts and squamous cell carcinoma in transplant recipients is the reason a resistant lesion here is examined rather than treated again. Removing it with the tissue sent for examination answers two questions at once, which is why surgery sits earlier on this route than on any other.

    Matched with

  • 3 Ordinary limited warts, on stable immunosuppression

    Not everything changes. A couple of hand warts in someone whose immunosuppression is stable are still treated with acid and filing, and still freezing if that fails — with a lower threshold for review, a longer expected clock, and the treating team told rather than bypassed.

    Matched with

The clinic library

The reference shelf behind the walk. Open any of it; none of it is needed to follow the route.

Understanding wartsWhat is happening in the skin, and who this guide is for

A wart is a patch of skin whose growth instructions have been rewritten by human papillomavirus. The virus enters through a small break — a graze, a bitten cuticle, softened skin on a changing-room floor — infects the basal cells of the epidermis, and drives them to divide far faster than the surrounding skin. The rough, raised surface is that overproduction piling up, and the dark specks people take for seeds or roots are capillaries drawn up into the growth and clotted. Nothing about a wart is deep: it sits entirely within the epidermis, above the layer that scars, which is why a treated wart leaves no mark and an over-treated one can. The immune system eventually recognises the infected cells and clears them, and the whole difficulty of this condition is that eventually is measured in months to years.

Who this guide is forAnyone with a rough growth on a hand or finger, a tender callus-like patch on a sole that hurts when squeezed from the sides, or a scatter of small flat bumps across the face and forearms. It is written especially for whoever has bought three different wart treatments and concluded that none of them work, because that is the single commonest way this condition is misread.

How to read itGenital and anal warts are a different pathway with different treatments, different transmission and different follow-up, and nothing on this page applies to them. Everything here concerns warts on ordinary skin. This page also assumes the growth is a wart: seborrhoeic keratoses, corns, calluses, molluscum contagiosum and — rarely but importantly — skin cancers all produce lumps that get treated as warts for months by people who never intended to gamble.

11Every therapy explainedWhat each one is, side effects, pregnancy

About the brand namesGeneric names carry this page. Wart removers are sold under many brand names in every market and the only line worth reading on any of them is the active ingredient: salicylic acid at 17% in a liquid or 40% in a plaster, with 'wart remover' as the stated purpose. That single line separates a licensed drug product from a skincare exfoliant containing the same molecule at a twentieth of the strength, and from the cosmetic 'wart' products that promise appearance rather than removal. Where a region is missing from a brands section, that reflects what we could verify rather than proof of absence.

Reading the labelThe label links below point to the primary product information or a national medicines source. Prescription treatments described on this page are used off-label for cutaneous warts in most markets, which is ordinary practice for this condition rather than a warning sign — but it does mean the label being linked frequently describes a different indication, and that is worth knowing when reading one.

On the shelfNo prescription needed · 2

Over the counter Salicylic acid wart removers Keratolytic destruction Strong evidence Generally fine in pregnancy

The one over-the-counter category with genuine meta-analytic support for treating warts, sold at strengths between roughly 17% and 40% as a licensed wart-remover drug product.

At the shelf, look for

Salicylic acid 17% liquid or 40% plaster, sold in the foot-care or first-aid aisle as a wart remover.

The active-ingredient line is the only thing worth reading, and it sorts the category instantly. A wart remover declares salicylic acid at 17% or 40% with 'wart remover' as its stated purpose; a skincare product declares it at 0.5% to 2% for blemishes and cannot do this job at any duration. Between the two licensed formats the choice is practical rather than clinical — a liquid suits an awkwardly shaped wart on a finger, a plaster survives a sock and a shoe better, and adherence over twelve weeks is the only variable that reliably separates outcomes. Both formats carry the same twelve-week instruction and the same exclusions.

Premium pricing on identical chemistry, and any pack whose promise is speed — nothing at this strength clears a wart quickly, and the packs that imply otherwise are selling the expectation that ends courses.

Browse every salicylic acid product in the Market →
How it works

Salicylic acid breaks the bonds between keratinocytes in the thickened layer over and around the wart, so successive layers of infected tissue soften and can be filed away rather than piling up. The mild persistent inflammation it produces is thought to contribute a second, immunological effect, which is one explanation for why untreated warts elsewhere sometimes fade during a course.

The usual course

Applied once or twice daily for common and plantar warts, with the softened layer filed back between applications, for up to twelve weeks — the duration printed on the label rather than a target invented here.

Where it sits on the route

It opens every route on this page because it is simultaneously the cheapest option, one of the best-evidenced, and the only one whose success depends almost entirely on something the reader controls.

Side effects people notice
  • Stinging on application, especially where the surrounding skin is exposed
  • Redness, soreness and peeling of the skin around the wart
  • Occasional chemical burn where the acid strays or is occluded too tightly
  • Temporary pale or dark discolouration of the treated skin
Worth knowing before starting
  1. Never on the face, on mucous membranes, on genital skin, on moles or birthmarks, or on hair-bearing warts
  2. Never on a foot affected by diabetes, neuropathy or impaired circulation
  3. Protect the surrounding skin — a ring of petroleum jelly or a precisely cut plaster keeps the acid where it belongs
  4. Not for use on skin that is already broken, infected or inflamed

Topical salicylic acid applied to a small area is generally regarded as low risk in pregnancy, and warts frequently multiply during it; the sensible modification is to treat a limited area rather than many warts at once, and to confirm the plan with a midwife or clinician.

The 3 options in this group
  • 17% collodion liquidPainted on daily, dries to a film, peels off with the softened layer. The format most trials used.
  • 40% medicated plaster or padA high-strength patch changed every couple of days — less fiddly, better suited to a sole under a sock.
  • Gels and sticksThe same chemistry in tidier packaging, chosen mainly for where the wart sits and how likely the film is to be rubbed off.
The evidence

Pooled randomised trials put clearance around 52% with salicylic acid against 23% on placebo, with a risk ratio for cure of roughly 1.6; head-to-head trials against professional cryotherapy have found no significant difference for plantar warts.

Read the official label
Over the counter Soaking, paring and occlusion Preparation and technique Promising Generally fine in pregnancy

The unglamorous technique layer around the acid — the part that separates a course that works from the identical product used ineffectively for the same twelve weeks.

At the shelf, look for

The cheapest emery boards sold in multipacks, and waterproof tape wide enough to cover the wart and a margin.

This is the one part of the shelf where spending more buys nothing at all. A multipack of disposable emery boards is better practice than a single good file, because the point is that each wart gets its own and it is thrown away rather than cleaned; the same logic applies to a cheap pumice used once on a verruca and binned. Waterproof tape matters more than it sounds: over twelve weeks the difference between a preparation that stays in contact overnight and one that ends up on a bedsheet is most of the difference between the two arms of a trial.

Electric callus removers and salon-grade files, which encourage filing far past the softened layer, and any device that has to be cleaned rather than discarded.

How it works

A wart builds a thickened, dead cap over itself, and on the sole body weight adds callus on top of that. Acid applied to that cap softens dead tissue that is already dead. Removing the softened layer between applications means each new application starts closer to living infected tissue, and occlusion keeps the preparation in contact through a working day instead of transferring it to a sock.

The usual course

A few minutes of soaking and gentle filing before each application, for as long as the course runs, with the file kept for that wart alone.

Where it sits on the route

It sits alongside the acid rather than below it because the two are one treatment. Trials that produced the clearance figures on this page tested a regimen with filing built in.

Side effects people notice
  • Soreness if filing goes past softened tissue into living skin
  • Bleeding, which means the filing has gone too deep and the virus has been given a fresh surface to spread onto
Worth knowing before starting
  1. Filing until it bleeds spreads the virus rather than removing it — softened white tissue only
  2. Files, pumice and clippers used on a wart do not go back into shared kit
  3. Filing is done by whoever is being treated or by an adult helping, never in a nail salon
  4. On a foot with diabetes or poor circulation, none of this is done at home

Nothing in soaking, filing or taping carries any pregnancy consideration; it is the mechanical half of a course and remains available throughout.

The 3 options in this group
  • Warm soak before applicationA few minutes of water softens the surface so acid penetrates rather than sits.
  • A dedicated emery board or pumiceOne per wart, never shared, never returned to a communal manicure kit.
  • Waterproof tape or a plaster over the topHolds the preparation in contact and stops the film being rubbed off inside a shoe.
The evidence

Paring and occlusion are standard components of the regimens tested in salicylic acid trials rather than separately randomised interventions, so their contribution is inferred from the protocols that produced the trial results rather than isolated.

Prescribed, applied to the skinCreams, gels and lotions · 1

Prescription · on the skin Prescription topicals Immune modulators and antiproliferatives Limited evidence Avoid in pregnancy

Creams a prescriber can supply that either recruit the immune system to the infected skin or interrupt the rapid cell division driving the growth.

How it works

Imiquimod stimulates local innate immune signalling, effectively raising an alarm at the site so that immune cells arrive and encounter the virus. Fluorouracil blocks a step in DNA synthesis, which affects the wart's fast-dividing cells more than the surrounding skin. Retinoids normalise the way keratinocytes mature and are the gentlest option for the thin, delicate, many-lesioned presentation on a face.

The usual course

Applied at home on a schedule set by the prescriber, over weeks to several months, with reviews built in rather than left open-ended.

Where it sits on the route

It is the first prescription rung for flat and facial warts, where the destructive methods that lead every other route carry an unacceptable scarring cost.

Side effects people notice
  • Redness, crusting and erosion at the application site, which is partly the intended effect
  • Flu-like symptoms with imiquimod in some people
  • Photosensitivity and prolonged inflammation with fluorouracil
  • Pigment change while treated skin settles, particularly on the face
Worth knowing before starting
  1. Used off-label for cutaneous warts in most markets, which is a reason for a prescriber to set the schedule rather than a reason to avoid them
  2. Fluorouracil is avoided in pregnancy and where there is a known dihydropyrimidine dehydrogenase deficiency
  3. Facial application needs a conservative schedule; the inflammation these produce is visible
  4. Not obtainable over a counter, and preparations sold online as equivalents are not

Fluorouracil and topical retinoids are avoided in pregnancy; imiquimod has limited data and is not used electively. Where warts appear or multiply during pregnancy, the usual approach is mechanical or to wait until afterwards.

The 3 options in this group
  • Imiquimod creamAn immune-response modifier applied at home over weeks to months.
  • Topical fluorouracilAn antimetabolite cream, often under occlusion, for resistant or numerous warts.
  • Topical retinoidsUsed particularly for flat warts on the face, where destructive methods carry a scarring cost.
The evidence

Trial data for these agents in non-genital warts are small and heterogeneous; the systematic reviews could not pool most of them, and their use rests substantially on clinical experience rather than large randomised comparison.

Prescribed, taken by mouthTablets and capsules · 1

Prescription · by mouth Oral retinoids for multiple resistant warts Systemic therapy Limited evidence Avoid in pregnancy

Tablets used off-label by specialists for the small group with many warts that have resisted everything else, particularly where the immune system is compromised.

How it works

Retinoids alter how keratinocytes proliferate and differentiate, which slows the overproduction the virus is driving and thins the growths from within rather than destroying them from the surface. Because the effect is systemic, it reaches every wart at once, which is the whole reason to consider a tablet for a skin infection.

The usual course

A course of some months under specialist supervision, with blood monitoring, and with strict pregnancy prevention requirements throughout and for a defined period afterwards.

Where it sits on the route

It is the last rung because the risk profile only makes sense against extensive disease that has exhausted everything below, most often in someone whose immune system cannot do this job unaided.

Side effects people notice
  • Dryness of lips, eyes, skin and nasal passages, in essentially everyone
  • Raised blood lipids and liver enzymes, monitored by blood tests
  • Muscle and joint aches
  • Hair thinning and increased skin fragility with prolonged use
Worth knowing before starting
  1. Powerfully teratogenic — pregnancy prevention requirements are absolute and extend well beyond the last dose, and for acitretin that period is measured in years
  2. Used off-label for warts and reserved for extensive resistant disease rather than offered for a single lesion
  3. Not combined with tetracycline antibiotics
  4. Alcohol converts acitretin into a longer-lived compound, which changes the pregnancy prevention period

MonitoringBlood tests for liver function and lipids before and during the course, and pregnancy prevention monitoring as required by the regulatory programme in the country of prescription.

Absolutely contraindicated in pregnancy and in anyone who might become pregnant during or after the course without the required precautions. This is the strictest single restriction on the page and it applies to a treatment used for a benign viral infection, which is itself a reason it sits where it does.

The 2 options in this group
  • AcitretinA systemic retinoid used in specialist practice for extensive resistant warts.
  • IsotretinoinThe same class by a different route, trialled for multiple recalcitrant common warts.
The evidence

Supported by small randomised trials in recalcitrant multiple warts reporting clearance well above placebo, in populations selected for having failed everything else — informative for that group and not generalisable beyond it.

Done in the clinicProcedures and devices · 7

Device Home freezing kits Self-applied cold destruction Limited evidence Pregnancy: case by case

Pressurised cold applied through a foam tip or applicator to freeze the wart at home, sold as an alternative to weeks of acid.

How it works

Rapid cooling forms ice crystals inside cells and ruptures them, destroying the infected tissue and provoking an inflammatory response that may help the immune system find the virus. The temperature reached is substantially warmer than the liquid nitrogen used in clinics, which is the source of both its safety margin and its weaker effect.

The usual course

A single application repeated at intervals stated on the pack, usually to a maximum of three or four attempts before the product itself directs the user elsewhere.

Where it sits on the route

It sits on the over-the-counter rung as an option rather than the recommendation, because it is what most people reach for when the acid feels too slow — and it is worth knowing before that purchase that the evidence runs the other way.

Side effects people notice
  • Sharp pain during and shortly after freezing
  • Blistering, sometimes blood-filled, over the following days
  • Lasting pale or dark marks where the skin has been injured
  • Damage to the nail if used close to a nail fold
Worth knowing before starting
  1. The same exclusions as the acids apply — not on the face, genital skin, moles, or a compromised foot
  2. Freezing over a nail fold risks the nail matrix and can produce permanent nail deformity
  3. Cold injury in skin that marks easily can leave a paler patch more visible than the wart
  4. Repeated attempts beyond the pack's limit are not a strategy; the pack's limit is the honest one

There is no systemic exposure to consider, so the question is practical rather than pharmacological: freezing hurts, blisters and marks, and most clinicians would suggest deferring an elective wart treatment of this kind rather than avoiding it outright.

The 2 options in this group
  • Dimethyl ether and propane applicatorsThe common supermarket format, reaching around minus fifty degrees at the tip.
  • Nitrous oxide devicesA colder pen-style variant sold in some markets.
The evidence

Evidence for home freezing devices is thin, and the pooled trial data for cryotherapy in general did not show a statistically significant advantage over placebo — the freezing that does outperform is the aggressive professional kind, which these devices cannot reproduce.

Done in the clinic Cryotherapy with liquid nitrogen Clinic-delivered cold destruction Promising Generally fine in pregnancy

Professional freezing, repeated on a rhythm of two to three weeks until the wart clears or the course is called.

How it works

Liquid nitrogen destroys tissue far more thoroughly than a home device, and the blister that follows lifts the infected epidermis away from the layer beneath. The inflammation is also part of the treatment: it recruits immune attention to a virus the body had been ignoring, which is why clearance sometimes continues between sessions.

The usual course

Sessions two to three weeks apart, with a limit set in advance rather than open-ended — commonly three to four attempts before the approach is reconsidered.

Where it sits on the route

It is the clinic's default first move after a completed over-the-counter course, and the tier where evidence for combining methods is strongest.

Side effects people notice
  • Significant pain during the freeze and for hours afterwards
  • Blistering, sometimes blood-filled, and a wound that takes a week or two to close
  • Lasting pigment change, more likely and more visible in deeper skin tones
  • Nerve injury where treatment sits over a finger's side, and nail deformity near the matrix
Worth knowing before starting
  1. Aggressive freezing clears more warts and causes more harm; the trade is deliberate and worth discussing before the first session
  2. Pigment loss after freezing can be permanent, and is a stronger consideration on visible skin and in richly pigmented skin
  3. Not appropriate for people with cold-related conditions such as cryoglobulinaemia or severe Raynaud phenomenon
  4. Repeating indefinitely because sessions are available is not a plan; a fixed number and a review point is

Freezing involves no drug absorption and is generally considered acceptable during pregnancy where treatment is wanted, though the pain and the blistering lead many clinicians and patients to postpone an elective course.

The 2 options in this group
  • Spray or cotton-bud applicationLiquid nitrogen at around minus 196 degrees, applied for a timed freeze.
  • Double freeze-thaw cyclesA second freeze after thawing, which the trial evidence supports specifically for plantar warts.
The evidence

Cryotherapy performed level with self-applied salicylic acid for plantar warts in a randomised trial, and outperformed both acid and watchful waiting for common warts in a primary-care trial; pooled analyses favour aggressive over gentle freezing and favour combining freezing with acid over either alone.

Done in the clinic Office-applied acids Clinic-delivered chemical destruction Promising Pregnancy: case by case

Strong acids applied by a clinician at concentrations far beyond anything sold across a counter, coagulating the wart tissue in place.

How it works

These agents denature the proteins of the infected tissue on contact, producing a controlled chemical burn that separates over the following days. Applied in a surgery rather than at home because the concentrations leave no margin for a slipped drop, and because the surrounding skin has to be masked before application.

The usual course

Applications every one to two weeks in the surgery, over a course of similar length to a freezing course, with the treated area kept covered between visits.

Where it sits on the route

It sits beside freezing rather than above it, because the trial that compared them found comparable clearance with less pain during treatment — which makes it a choice about fit rather than a step up in strength.

Side effects people notice
  • A chemical burn and subsequent wound at the treated site
  • Pain in the days after application rather than during it
  • Staining of skin, black and temporary, from silver nitrate
  • Scarring where the burn extends past the wart
Worth knowing before starting
  1. These concentrations are not obtainable or usable outside a clinical setting, and attempting the same with stronger shop-bought products causes real injury
  2. The surrounding skin has to be protected before application
  3. Not used on the face, near the eyes, or on mucosal skin
  4. The same foot exclusions apply as for every destructive method

Systemic absorption from a small treated area is negligible, but these are elective treatments that produce wounds, and the usual position is to weigh the case individually rather than proceed by default.

The 3 options in this group
  • Monochloroacetic acidApplied in the surgery at intervals; trialled directly against freezing in general practice.
  • Trichloroacetic acidA related agent used at various concentrations on a weekly rhythm.
  • Silver nitrateA caustic pencil or solution, cheap and widely used, on thinner evidence.
The evidence

Monochloroacetic acid matched cryotherapy for common warts in a randomised primary-care trial and matched cryotherapy-plus-acid for plantar warts, with less treatment pain; silver nitrate cleared common warts in a small placebo-controlled trial but rests on much thinner evidence overall.

Done in the clinic Cantharidin blistering Clinic-applied blistering agent Limited evidence Pregnancy: case by case

A blistering agent derived from beetle secretion, painted on in clinic and removed hours later, which lifts the wart off inside a blister.

How it works

Cantharidin causes the epidermal cells to separate from one another, so a blister forms within the epidermis and the roof of that blister carries the infected tissue away as it heals. Because the split happens above the layer that scars, the technique can clear a wart without leaving a mark.

The usual course

Applied in the surgery, occluded for a set number of hours, washed off at home, and repeated at intervals of a few weeks where the first application helped.

Where it sits on the route

It sits in the middle tier as a painless-at-the-time alternative for people who cannot tolerate freezing, on evidence that is honestly thinner than its popularity in some clinics implies.

Side effects people notice
  • A blister at the site, sometimes large and uncomfortable
  • A ring of new warts around the treated blister, a recognised and unwelcome pattern
  • Pain as the blister forms, several hours after leaving the clinic
  • Temporary pigment change while the site heals
Worth knowing before starting
  1. Used on warts off-label in most markets; the approved cantharidin product is licensed for molluscum contagiosum, which is a different condition
  2. Never applied by the patient and never left on beyond the stated time
  3. Not used on the face or on genital skin
  4. Availability varies enormously by country and by whether a compounding pharmacy is reachable

Data in pregnancy are lacking and the treatment is elective, so the usual course is to defer rather than to establish safety on a wart.

The 2 options in this group
  • Compounded cantharidin solutionsApplied in clinic, occluded for a set period, then washed off.
  • Combination formulations with salicylic acid and podophyllinCompounded preparations used in some centres for resistant warts.
The evidence

Evidence for cantharidin in cutaneous warts is small-scale and largely uncontrolled, with the better trial data belonging to a different condition entirely.

Done in the clinic Curettage, electrosurgery and blunt dissection Surgical removal Limited evidence Pregnancy: case by case

Physical removal under local anaesthetic, reserved for single stubborn warts rather than offered early.

How it works

The infected tissue is removed or destroyed outright rather than persuaded to leave. The limitation is anatomical: warts sit in the epidermis but surgical removal necessarily reaches the layer beneath, so the technique trades a wart for a scar, and on a weight-bearing sole that scar can be more troublesome than the growth was.

The usual course

A single session under local anaesthetic, with a wound taking two to three weeks to heal and activity limited afterwards where the site is on a foot.

Where it sits on the route

It sits high on the ladder despite being conceptually the simplest option, because it is the only one on this page that reliably exchanges a temporary problem for a permanent one.

Side effects people notice
  • A permanent scar at the treated site
  • Pain during healing, and difficulty walking where the site is weight-bearing
  • Recurrence at or around the scar, which is common enough to be expected rather than surprising
  • Bleeding and, occasionally, infection of the wound
Worth knowing before starting
  1. A scar on the sole of a foot can hurt for longer than the wart did — this trade is the reason surgery sits late rather than early
  2. Recurrence in a surgical scar is harder to treat than the original wart
  3. Not a first-line option for numerous warts, and impractical for mosaic plaques
  4. Reserved for lesions where the diagnosis is also in question and tissue is worth examining

Local anaesthetic and minor surgery are compatible with pregnancy where they are necessary; a wart is rarely necessary, so the usual advice is to wait.

The 3 options in this group
  • Curettage with cauteryScraping the wart out under local anaesthetic and sealing the base.
  • Blunt dissectionSeparating a plantar wart from the surrounding tissue along its natural plane.
  • ElectrosurgeryDestroying the tissue with heat generated by current.
The evidence

Supported mainly by older uncontrolled series rather than randomised comparison, with clearance rates that look impressive on paper and recurrence rates that complicate them.

Done in the clinic Intralesional therapy Injection into the wart Promising Avoid in pregnancy

Injecting an agent into the wart itself, either to force the immune system to notice the infection or to poison the dividing cells directly.

How it works

The immunotherapy versions exploit an existing immune memory: injecting an antigen the body already recognises creates a local inflammatory response, and the immune cells recruited to it encounter the viral proteins alongside. That is why treating one wart can clear untreated warts elsewhere, which no destructive method achieves. The antimitotic versions work differently and locally, halting cell division in tissue that is dividing far too fast.

The usual course

Injections every two to three weeks for a small number of sessions, with response judged across the course rather than after one.

Where it sits on the route

It sits near the top because it is where the strategy changes: everything below destroys one wart at a time, and this is the first tier whose mechanism can clear warts nobody treated.

Side effects people notice
  • Pain during injection, which is the principal reason people decline the tier
  • Flu-like symptoms after antigen injection
  • With bleomycin, tissue damage, nail changes and Raynaud phenomenon in treated digits
  • Local swelling and blistering in the days afterwards
Worth knowing before starting
  1. Used off-label for warts; preparations and protocols vary widely between centres
  2. Bleomycin is not used in pregnancy, in people who are immunosuppressed, or in digits with impaired circulation
  3. Antigen immunotherapy requires prior exposure or vaccination to the antigen used to have any effect
  4. Access depends heavily on local practice, and availability is not evenly distributed

Bleomycin and fluorouracil are contraindicated in pregnancy, and the immunotherapy antigens are not used electively during it either. This whole tier waits.

The 3 options in this group
  • Immunotherapy antigensCandida, measles-mumps-rubella and tuberculin preparations injected to provoke recognition of the virus.
  • BleomycinAn antimitotic injected directly into resistant warts, used in specialist settings.
  • Fluorouracil with local anaestheticAn antimetabolite injection used for palmoplantar and common warts in some centres.
The evidence

Network meta-analysis of plantar wart trials placed intralesional bleomycin among the few treatments significantly better than no treatment; the immunotherapy antigens are supported by numerous small randomised trials with wide variation in preparation and protocol.

Done in the clinic Laser and photodynamic therapy Light-based treatment Promising Pregnancy: case by case

Specialist light-based options for warts that have survived everything below them, delivered in dermatology settings rather than general practice.

How it works

Pulsed dye laser heats the dilated capillaries that supply the wart, cutting off its blood supply while sparing the surface. Ablative lasers remove the tissue outright, with the plume they generate carrying viral particles and requiring proper extraction. Photodynamic therapy uses a compound the abnormal cells take up preferentially, then activates it with light so the damage concentrates where the compound accumulated.

The usual course

Several sessions spaced by weeks, in a specialist setting, with cost and access frequently the deciding factors rather than clinical suitability.

Where it sits on the route

It sits at the specialist end because access, cost and the spread in reported results all make it a considered choice rather than a next step.

Side effects people notice
  • Pain during treatment, often requiring local anaesthesia
  • Blistering, crusting and a healing period of one to two weeks
  • Pigment change and, with ablative techniques, scarring
  • A stinging, burning session with photodynamic therapy that many find harder than expected
Worth knowing before starting
  1. Rarely funded by public systems for warts, and priced per session in private ones
  2. Ablative laser generates infectious plume and needs proper extraction — this is a reason it belongs in equipped settings
  3. Reported success rates vary widely between studies using different devices and settings
  4. Photosensitising agents make the treated skin sun-sensitive for a period afterwards

Light-based treatment involves no systemic drug, but the photosensitising agents used in photodynamic therapy have limited pregnancy data and these are elective procedures, so deferral is usual.

The 3 options in this group
  • Pulsed dye laserTargets the blood vessels feeding the wart rather than the wart itself.
  • Ablative lasersCarbon dioxide and erbium systems that vaporise the tissue directly.
  • Photodynamic therapyA light-activated agent applied first, then illuminated, destroying the treated tissue.
The evidence

Pooled trial data support photodynamic therapy for cutaneous warts, and laser comparisons report wide ranges of complete response with settings differing substantially between studies, which limits how far one centre's results transfer to another.

4Telling the patterns apartAnd what else looks like warts

There is no severity grade for warts in the way there is for acne or psoriasis. What clinical guidance sorts them by is form and site, because those decide the thickness of skin a treatment has to cross, what may legally be applied at home, and how much scarring risk any destructive method carries.

The patterns Tap a card to see what it looks like

What changes the plan, whatever the pattern

  • A suppressed immune systemClearance of a wart is immune work, so the medication that protects a transplanted organ or calms an autoimmune disease also removes the mechanism this condition normally resolves through. Warts in that setting are more numerous, more persistent, and more likely to need specialist management rather than a longer course of the same thing.
  • Diabetes, neuropathy or poor circulation in the feetEvery over-the-counter wart product carries the same warning against use on a foot in this situation, and it is not boilerplate: these preparations destroy tissue deliberately, and a foot that heals slowly or cannot report pain converts a small chemical burn into an ulcer. Foot warts here belong with a clinician or podiatrist from the first appointment.
  • Many warts at once, or warts that keep appearingTreating twenty warts individually is neither practical nor how clinics approach it. High numbers shift the strategy from destroying each growth toward provoking an immune response that reaches all of them, which is the logic behind the immunotherapy tier and the reason a single treated wart can be followed by distant ones disappearing.
  • Skin that marks easily after injuryFreezing and other destructive methods work by injuring skin, and skin that responds to injury with lasting pale or dark patches can be left with a mark more visible than the wart was. This is a real trade-off in deeper skin tones and on the face, and it is a legitimate reason to prefer the slower chemical route or to wait.

Look-alikes Not every warts is warts

The pattern behind that list is worth stating plainly: everything in it is either harmless and untreatable by this page's methods, or serious and delayed by them. Both failure modes cost the same thing — months — which is why a growth that does not fit the description in the stage above is worth showing to someone before a twelve-week course begins.

2When the rules changeDuring pregnancy · In children

Two groups the main routes above quietly assume away, and for whom the ordinary answer changes enough to be worth setting out separately.

During pregnancy

Warts frequently multiply during pregnancy and frequently settle afterwards, which shapes the whole approach: the goal is usually to hold the situation comfortably rather than to clear it on a deadline.

Still on the table
  • Topical salicylic acid on a limited area, generally regarded as low risk and usually confirmed with a midwife or clinician
  • Soaking, filing and occlusion, which carry no pregnancy consideration at all
  • Every containment measure on this page — covering, footwear, keeping tools separate
  • Watchful waiting, which is a stronger option here than at any other time
Off the table
  • Systemic retinoid therapy, which is absolutely contraindicated and remains so for a defined period after any course
  • Topical fluorouracil and topical retinoids
  • Elective destructive procedures, commonly deferred rather than prohibited

The distinction worth holding is between contraindicated and deferred. The systemic tier is genuinely off the table; freezing is not pharmacologically problematic and is usually postponed because it is an elective procedure that hurts and blisters, which is a different kind of no.

3Skincare alongside therapyKeeping a treatment tolerable

Supporting care on this page has two jobs, and neither is treating the wart. The first is protecting the ring of ordinary skin around a growth from a preparation designed to dissolve tissue. The second is containment — stopping one wart from becoming a row of them while the course runs.

Pick the therapy that is underway

Keep everything else gentle and simple. The treatment does the work.

While a twelve-week course is running

The preparation is doing controlled damage, and the surrounding skin is not the target. Protecting that margin properly is what makes twelve weeks tolerable, and tolerability is the only variable this treatment's success actually depends on.

  • Ring the healthy skin around the wart with an occlusive ointment before each application, or cut a hole in a plaster to the exact size of the growth
  • Moisturise the surrounding skin in the morning, away from the treated area, so it stays intact rather than cracking
  • Take a night off where the margin becomes sore, and improve the protection rather than abandoning the course
  • Wash hands after every application, and keep the file, pumice and any towel used on the site out of shared circulation
  • Applying to skin that is already broken, weeping or infected
  • Filing until the site bleeds, which spreads the virus into fresh skin rather than removing it
  • Layering exfoliating skincare over or beside the treated area, which compounds irritation the acid is already causing

Applies to

This page concerns a viral infection rather than a skin routine, and the two intersect at exactly one point: the ordinary skin around a treated site needs protecting for twelve weeks. If the same visit is meant to sort out a routine as well, these are the starting points. Build a routine from a profile · The personalised view of this site

None of this treats the infection, and it is worth being clear that it is not sold as doing so. What it does is protect the twelve weeks the actual treatment needs, which on this condition is the scarcer resource. The most common reason a course ends prematurely is not boredom but a sore, cracked margin of healthy skin that made the nightly application unpleasant — and that is entirely preventable with an ointment ring and a correctly cut plaster.

5What to expectWhy treatments get abandoned

Two expectations need resetting before anything on this page works, and they pull in opposite directions. The first is about speed: this treatment produces no visible result for weeks, by design, because it works through dead tissue that has to be removed a layer at a time before living infected skin is reached. An unchanged wart at week four is a course running correctly. The second is about certainty: even completed properly, around half of courses do not clear the wart, and roughly a quarter of warts clear on placebo, which is the same fact viewed from the other side — the immune system finishes many of these regardless. Holding both at once produces the right posture, which is patience without illusion. Warts are a benign infection that resolves eventually, treatment shifts the odds of that happening sooner rather than guaranteeing it, and the treatments that shift the odds most are also the ones that hurt, mark or scar. Everything on this page is a negotiation between those facts.

  1. 1Count from the first application, never from the purchase

    those dates are frequently weeks apart

  2. 2Judge by surface texture and returning skin lines, not by size

    size is the last thing to change

  3. 3Missed days extend the course rather than ending it, but they are missed weeks, not calendar weeks
  4. 4A fortnightly photograph in the same light is the only reliable record of change this slow
  5. 5Sore surrounding skin means better protection, not a stopped course

    that is where most courses actually die

Keeping an eye on itNothing here needs monitoring in a clinical sense. What does need recording is the count: which day the first application happened, roughly how many days were missed, and a photograph every fortnight. Those three facts turn a vague sense that something has been tried for ages into the specific answer a clinician needs at the twelve-week mark.

0On the horizonPhase 3 and newly approved only

Nothing here changes what to do todayNothing in this section changes what is worth doing now, and on this condition the emptiness of it is itself the finding — the best-evidenced treatment here is decades old, costs very little, and is available without an appointment.

2023 Just arrivedCantharidin approved in the United States — for molluscum contagiosum, not warts

A cantharidin product was approved by the FDA in July 2023 as a topical treatment for molluscum contagiosum in adults and children aged two and over. It is worth naming here precisely because it is so easily misread: cantharidin has been used off-label on warts by clinics for decades, an approval now exists for the molecule, and the approval is for a different condition. Cantharidin applied to a wart remains an off-label, compounded, clinic-delivered practice, and the evidence supporting it there has not changed.

Applying a phase-3 floor to cutaneous warts leaves the section empty, and padding it would misrepresent a field that is genuinely quiet. Most current research activity sits at the small-trial end — intralesional immunotherapy protocols, device-based heating, and formulation work aimed at getting existing agents through thick plantar skin — and almost none of it is running the kind of large randomised comparison that would move a guideline. The claim to treat most sceptically remains the private clinic's: light-based and device treatments are marketed considerably ahead of the evidence supporting them, and their reported response rates vary widely between studies using different settings.

Treatments for cutaneous non-genital warts at phase 3 or later, or recently reaching a market, with the stage verifiable from a regulator or trial registry rather than from a manufacturer's outlook. Last reviewed 2026-09-01.

Worth knowing if anything here actually changes?

A genuinely new treatment for cutaneous warts would be notable precisely because this field has been static for so long, and it is the kind of development the site's newsletter covers with the trial data alongside the announcement rather than instead of it.

As always, plainly: this is the general Dermington newsletter, not a nail-specific alert. Unsubscribe freely; the address is never sold; no part of this page earns us anything.
16SourcesThe guideline and the studies behind the order
The guideline this pathway follows British Association of Dermatologists' guidelines for the management of cutaneous warts 2014 (opens in a new tab) British Association of Dermatologists · Sterling JC, et al. Br J Dermatol. 2014;171(4):696-712.
The guideline this pathway follows Topical treatments for cutaneous warts (Cochrane review) (opens in a new tab) Cochrane Skin Group · Kwok CS, et al. Cochrane Database Syst Rev. 2012;(9):CD001781.

The studies this page leans on, with what each one is doing here. Every PubMed link was resolved against the National Library of Medicine's own record during authoring; where a source could not be confirmed that way, no link is attached rather than a plausible one.

  1. 2014 British Association of Dermatologists' guidelines for the management of cutaneous warts 2014 (opens in a new tab) Sterling JC, et al. · British Journal of Dermatology The structure of this page — ladder order, the place of each tier, and the position of the destructive and immunological options.
  2. 2012 Topical treatments for cutaneous warts (opens in a new tab) Kwok CS, et al. · Cochrane Database of Systematic Reviews The salicylic acid risk ratio of 1.56 against placebo, the finding that aggressive freezing outperforms gentle, and the null result for duct tape.
  3. 2011 Efficacy of topical treatments for cutaneous warts: a meta-analysis and pooled analysis of randomized controlled trials (opens in a new tab) Kwok CS, Holland R, Gibbs S · British Journal of Dermatology The pooled cure rates quoted throughout — 23% on placebo, 52% with salicylic acid, 58% combining acid with freezing.
  4. 2011 Cryotherapy versus salicylic acid for the treatment of plantar warts (verrucae): a randomised controlled trial (opens in a new tab) Cockayne S, et al. · BMJ The finding that self-applied acid and professional freezing were equally effective for warts on the sole, at twelve weeks and at six months.
  5. 2010 Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial (opens in a new tab) Bruggink SC, et al. · CMAJ The site-dependent result behind the branch split — freezing ahead for common warts, no meaningful difference between freezing, acid and waiting for plantar warts.
  6. 2015 Monochloroacetic acid application is an effective alternative to cryotherapy for common and plantar warts in primary care: a randomized controlled trial (opens in a new tab) Bruggink SC, et al. · Journal of Investigative Dermatology The placement of office-applied acid level with freezing rather than below it, and the note about less pain during treatment.
  7. 2013 Natural course of cutaneous warts among primary schoolchildren: a prospective cohort study (opens in a new tab) Bruggink SC, et al. · Annals of Family Medicine The figure that half of primary schoolchildren with warts are clear within a year untreated, and that younger children clear faster.
  8. 1963 Natural history of warts. A two-year study (opens in a new tab) Massing AM, Epstein WL · Archives of Dermatology The original observational work establishing that untreated warts resolve over a period of years, which every later treatment trial is measured against.
  9. 2007 Efficacy of 10% silver nitrate solution in the treatment of common warts: a placebo-controlled, randomized, clinical trial (opens in a new tab) Ebrahimi S, et al. · International Journal of Dermatology The inclusion of silver nitrate among the office-applied options, and the honest characterisation of its evidence as thin.
  10. 2020 Evaluation of different concentrations of hydrogen peroxide solution (3% and 6%) as a potential new therapeutic option of nongenital warts: A randomized controlled triple-blinded clinical trial (opens in a new tab) Mahran AM, et al. · Journal of Cosmetic Dermatology The lower-evidence entry for hydrogen peroxide, including the occlusion protocol and the single reported side effect.
  11. 2002 The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart) (opens in a new tab) Focht DR 3rd, Spicer C, Fairchok MP · Archives of Pediatrics & Adolescent Medicine The positive half of the contradictory duct tape evidence, and the origin of a remedy that outlived its own replication.
  12. 2007 Duct tape for the treatment of common warts in adults: a double-blind randomized controlled trial (opens in a new tab) Wenner R, et al. · Archives of Dermatology The controlled replication that found no advantage over an inactive covering, which is why duct tape sits in the lower-evidence section.
  13. 2024 Topical antimitotic treatments for plantar warts are more beneficial: A Bayesian network meta-analysis of randomized controlled trials (opens in a new tab) Xu Y, et al. · Journal of Evidence-Based Medicine The standing of intralesional bleomycin among the few plantar wart treatments significantly better than no treatment.
  14. 2005 Cutaneous warts: an evidence-based approach to therapy (opens in a new tab) Bacelieri R, Johnson SM · American Family Physician The primary-care framing of this condition, and the position that most warts are managed without referral.

Further reading

Everything above traces to the sources below. Warts are unusually well served at the top of the evidence pyramid and unusually poorly served in the middle: one national guideline and two large syntheses, then a very long tail of small trials that none of them could pool.

Guidelines and systematic reviews The BAD guideline supplies the structure of this page; the two syntheses supply the numbers quoted throughout.
Patient information Written to be read rather than cited, and useful for checking what a health system will and will not fund.

Skip the shelf and go straight to the clinic when…

  • SoonA growth that bleeds, ulcerates, or grows steadily

    Squamous cell carcinoma and other skin cancers imitate warts convincingly, particularly on sun-exposed skin and in older adults, and the imitation is good enough that treating first and looking later is a genuine risk. Bleeding without injury, an eroded centre, or steady enlargement over weeks changes the question from which treatment to which diagnosis.

  • Book inWarts in the genital or anal area

    Anogenital warts are managed on an entirely separate pathway, with different treatments, a transmission conversation, and follow-up considerations that do not apply to a wart on a finger. No product on this page may be applied there, and every wart-remover label says so explicitly.

  • SoonAny wart on a foot belonging to someone with diabetes, neuropathy or poor circulation

    Wart treatments destroy tissue on purpose. In a foot that heals slowly, has reduced blood supply, or cannot feel a chemical burn developing, that controlled destruction becomes an ulcer, and foot ulcers in these groups escalate badly. This combination moves foot warts to a clinician or podiatry service from the outset.

  • Book inNumerous, spreading or unusually stubborn warts alongside immune suppression

    Extensive warts in someone taking immunosuppressive medication, living with a transplant, or with a known immune condition are not simply more of the same problem. Clearance depends on immune recognition that is deliberately dampened in these groups, and there is a recognised association between long-standing viral warts and skin cancer in transplant recipients that makes specialist oversight the right setting.

  • Book inA wart in a child that is being picked, bitten or spread along scratch lines

    Not dangerous, but genuinely worth acting on: the virus travels from a wart into any break in skin nearby, so picking and biting convert one wart into a row of them and periungual warts into a nail-fold problem that is much harder to treat. Covering it is the intervention, and it costs nothing.

Any of these means the over-the-counter walk is the wrong place to start. The clinic door is where the route begins instead.

Therapy
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