The science
The measurable effects of this mask come from occlusion and humectancy, and the formula is unusually well built for both. A hydrogel sheet traps water against the stratum corneum for the duration of the wear, temporarily raising corneocyte hydration and flattening fine dehydration lines; that alone accounts for much of the plumping any sheet mask produces. What distinguishes this serum is the layering of hyaluronates by molecular weight. High-molecular-weight sodium hyaluronate and a hyaluronate crosspolymer form a water-holding film on the surface, while hydrolysed and low-weight fragments have been shown in ex vivo skin models to reach the upper epidermis and improve hydration measured by corneometry for several hours after application. Eight forms are listed, which is more for marketing than mechanism, but the spread of sizes is what produces the combination of immediate surface plumping and a next-morning effect that a single-weight hyaluronic acid would not.
Niacinamide, placed fourth, is the ingredient with the strongest evidence for benefit beyond a day. Controlled trials of topical niacinamide at two to five percent over eight to twelve weeks show increased ceramide synthesis, reduced transepidermal water loss and a modest reduction in hyperpigmentation, and a daily mask is a plausible if expensive way to deliver it. Trehalose, a disaccharide, protects proteins and membranes against dehydration stress and is well documented as a humectant; placed ahead of the hyaluronic acids, it also guards against the reverse-osmosis drying that can occur when a gel sheet is worn too long.
The PDRN, listed as sodium DNA, is the ingredient whose evidence is most often misapplied. Polydeoxyribonucleotide has a genuine literature in wound healing and tissue repair through adenosine A2A receptor activation, but that evidence comes from injected and topical wound-care use on damaged tissue, not from short-contact cosmetic application on intact skin. On a sheet mask it functions as a large, hydrophilic, film-forming polymer with some anti-inflammatory activity; no controlled study shows topical cosmetic PDRN regenerating skin. Hydrolysed collagen is likewise a surface humectant, since intact collagen cannot cross the stratum corneum. Anua's reported one-use improvements in deep hydration and plumping come from a brand-commissioned test at a Korean dermatological testing institute on twenty-two women aged 44 to 68, measured ten minutes after a single application; they are consistent with the humectant-and-occlusion mechanism and describe a temporary effect, not independent evidence of lasting benefit.