Lierac Cica-Filler Anti-Wrinkle Repairing Serum 30 ml three ampoule set
Promising for Aging
What makes this different

Most bakuchiol serums in the U.S. market come from indie brands leaning into 'natural retinol alternative' positioning. Lierac's twist is the cure-style ampoule packaging plus a botanical 'cica' trio (Alchemilla, Ivy, Horsetail) standing in for the usual Centella complex, all tuned for a 30-day course rather than open-ended use. It's the French pharmacy answer to 'I want retinol results without the retinol routine.'

Lierac

Lierac Cica-Filler Anti-Wrinkle Repairing Serum Review

French Pharmacy Anti-Aging Cure Serums serum pharmacy brand Paraben free Not cruelty free

A French-pharmacy bakuchiol cure that earns its place in your routine if retinol has burned you out — three sealed ampoules, thirty days, smoother fine lines without the redness tax. The price-per-millilitre is its only real friction; the ingredient logic and tolerability are sound.

Price $69.00 30 ml (3 x 10 ml ampoules)
Shopper rating 4.3 ★★★★★ 850 reviews
On the market 2018 Made in France
Buy at Amazon ♥
Verdicts

How well it fits each concern

Lierac sells Cica-Filler primarily through European pharmacy channels and selected U.S. importers, which keeps the independent review volume moderate rather than CeraVe-scale. The scoring here weighs the bakuchiol and peptide evidence base, the silicone-rich vehicle, and the per-millilitre pricing math against several hundred retailer reviews — useful enough to read pattern, not deep enough to settle every question about long-term tolerance across skin types.

One verdict per concern. Open a row for the reasoning; the receipt has every source.

The scaleRecommendedGoodSupportingEarly evidenceNot for thisAvoidhow it works

Promisingfor AgingBakuchiol has trial-level evidence for aging but no guideline or regulatory standing yet — promising, short of a recommendation; the other actives here are not yet assessed for it.Receipt3 sources on the row · concentration not declared; studied range 0.5% · row checked Jul 17, 2026 · rule R9p, same reading on 4,872 products · open the receipt

The case for it

  1. Bakuchiol has at least one trial behind it for this concern but no guideline or regulatory standing yet.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Moderate evidenceStandard tolerabilityNo reviews read yet

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Promising” is the verdict on 4,872 of 45,446 concern verdicts across the catalog; rule R9p decided 4,872 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All aging products →

Good choicefor DehydrationHyaluronic Acid is a reference standard by mechanism for dehydration; this serum carries it.Receipt1 source on the row · concentration not declared; studied range 0.1% · row checked Jul 17, 2026 · rule R5, same reading on 9,843 products · open the receipt

The case for it

  1. Sodium Hyaluronate is a reference standard by mechanism for this concern — an established physical action, not a trial result.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Limited evidenceStandard tolerabilityNo reviews read yet

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Good choice” is the verdict on 10,340 of 45,446 concern verdicts across the catalog; rule R5 decided 9,843 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All dehydration products →

Avoidfor Compromised Skin BarrierThis formula carries fragrance — a known trigger for compromised skin barrier — so it is not a fit however good its actives are.Receiptread from the ingredient list: fragrance · rule R1, same reading on 1,307 products · open the receipt

The case for it

  1. Bakuchiol has no evidence row yet for this concern — it is in the research queue.
  2. The formula carries a known trigger for this concern, which decides the verdict before any efficacy question.

Not from a trial rowCarries a triggerNo reviews read yet

What would change this: Removing the trigger named above would let the actives be judged on their own.

Same rule for everyone. “Avoid” is the verdict on 1,912 of 45,446 concern verdicts across the catalog; rule R1 decided 1,307 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All compromised skin barrier products →

Where our review and the verdict differ. The review below was written on the formulation and the published trials; the verdicts above apply the stricter standing test in our methodology — an active earns a recommendation only with guideline or regulatory standing for the concern. Where the two disagree, the verdict is Dermington’s position.

A verdict is Dermington’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.10-r231 · engine 5.2.0 · how we decide · this product’s receipt

Reader poll · Town SquareQuestion 1 of up to 3

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No account neededOne answer each, change it any timeCounted only in anonymous totalsHow the Square counts →
Assessment

Pros & cons

What it does well 8

  • Bakuchiol-led anti-wrinkle effect without retinol irritation or purging
  • Acetyl Hexapeptide-8 pairs well for expression-line softening
  • Sealed ampoule packaging keeps the actives oxidation-resistant
  • Silicone-soft texture sits beautifully under makeup
  • Compatible with sensitive and post-procedure skin in most cases
  • Pregnancy-friendly active profile (subject to OB-GYN clearance)
  • Defined 30-day cure makes results easier to evaluate honestly
  • Visible day-one optical blur from soft-focus powders and HA

Where it falls short 5

  • Roughly $70 for 30 ml is steep on a per-millilitre basis
  • Contains parfum, ruling it out for fragrance-sensitive users
  • Ampoule format is fussier than a pump and harder to travel with
  • Effect is gentler than a stable prescription retinoid
  • No published bakuchiol or peptide concentrations to verify dose
Review

The full review

There's something almost defiantly old-fashioned about a serum that comes in three sealed glass ampoules and asks you to commit to a finite, thirty-day course. Lierac's Cica-Filler Serum is that kind of product. While the rest of the anti-aging market trains you to buy a 30 ml bottle and use it indefinitely, the French pharmacy approach here is closer to a treatment than a daily habit: you snap the seal, dose for roughly ten days, finish the second ampoule, finish the third, and walk away with skin that has been through what Lierac calls a cure. That structural choice is what makes this serum interesting before you even read the INCI list.

Open the box and the formula's intent is just as deliberate. The first listed active is bakuchiol — a meroterpene from Psoralea corylifolia that modulates collagen-related pathways in a way that resembles retinol's outcome without retinol's irritation profile. Sitting beside it is Acetyl Hexapeptide-8, better known as Argireline, the peptide aimed at expression lines around the forehead and eyes. Sodium hyaluronate handles immediate plumping, and a botanical trio of Alchemilla Vulgaris, Hedera Helix, and Equisetum Arvense plays the soothing 'cica' role. Notably, there is no traditional Centella Asiatica here — Lierac's interpretation of cica leans on its own French herbal vocabulary, which is the kind of small editorial decision that signals a brand confident in its own playbook. Tocopheryl acetate keeps the bakuchiol from drifting toward oxidation, and a generous silicone fraction gives the serum its signature soft-focus glide.

The texture is the first thing you notice on application: a gel-fluid that breaks into a silicone-velvet slip somewhere between a primer and a watery serum. There's a faint, clean floral parfum that disperses within a few minutes — if you're rosacea-prone or pregnant and avoiding scent, this is the one detail that will matter to you, because everything else in the formula reads quite calm. After application, skin looks slightly blurred in good light, which is the optical filler effect Lierac promises on the box and which is genuinely there, not just marketing language. Day one delivers that immediate visual smoothing. The real interest begins around week two, when fine lines around the outer eye start to look softened in a way that doesn't reset after washing your face the next morning.

What this serum is not is a heavy-hitter for deep wrinkles or a substitute for a stable, well-tolerated prescription retinoid. Bakuchiol's mechanism is gentler than tretinoin's by design, and that's both its appeal and its limit. If you've been on tretinoin for five years and you've adapted, this won't outperform what you already have. But if you're in the camp that has tried retinol, broken out, gotten flaky, taken three weeks off, and never quite gotten back on the wagon — which is most people, if we're being honest — this is the kind of product that lets you make visible progress on lines without a recovery curve.

The ampoule format takes some getting used to. You snap a small glass vial, transfer drops with the included dropper, and try to ration the 10 ml across ten days. In practice the ampoule sits on the bathroom counter and you forget which day you're on. The hygienic upside is real: bakuchiol oxidizes if mishandled, and the sealed format keeps each ampoule fresh until the moment you open it. The lifestyle downside is also real: it's fussier than a pump, and it isn't a packaging format that travels gracefully.

The sensorial experience under makeup is one of this serum's quiet wins. Silicone-rich serums get a bad reputation for pilling, but the soft-focus particles here are blended to disappear into skin, and foundation goes on more evenly than usual after twenty minutes of settle time. You can absolutely run this in your morning routine without re-engineering your makeup; many users report doing so for the optical smoothing effect alone.

Where the math gets tighter is value. Roughly seventy U.S. dollars for thirty millilitres across three ampoules works out to a per-millilitre cost that lands closer to mid-tier serums than to pharmacy staples, and Lierac's pharmacy-brand pricing in the U.S. market has always been steeper than its French retail price suggests. The cure framing helps justify the spend — you're buying a defined outcome, not a perpetual subscription — but if you respond well and want to keep going, the next purchase resets that calculus. A reasonable approach is to run a Cica-Filler Serum cure twice a year alongside a daily, less expensive bakuchiol or peptide moisturizer the rest of the time.

The ingredient logic is sound, the formulation is competent, and the tolerability is genuinely above average — there's no purge, no flake, no photosensitivity warning to manage. What it asks of you is discipline: stay on the thirty-day course, pair it with daily SPF, and don't expect dramatic single-week transformations. What it gives back is smoother fine lines, a softer surface, and the rare experience of an anti-aging routine that doesn't feel like punishment.

The science

Bakuchiol's profile as a retinol-functional alternative is anchored in a 2019 British Journal of Dermatology study by Dhaliwal and colleagues, which compared 0.5% bakuchiol cream against 0.5% retinol cream over twelve weeks and found comparable improvements in wrinkles and pigmentation, with bakuchiol producing significantly fewer adverse events such as scaling and stinging. That study is the most cited reason a formulation like Lierac's is built around bakuchiol rather than a retinoid, and it informs the brand's pitch of 'retinol-style smoothing without retinol downtime.' What that study does not tell us is the specific bakuchiol concentration Lierac is dosing here, which is the limit of evaluating this serum on the bakuchiol mechanism alone.

The peptide story rests on Acetyl Hexapeptide-8 (Argireline), originally developed by Lipotec and studied for its proposed inhibition of SNARE-complex assembly in dermal layers — a mechanism intended to reduce the muscle-related component of expression lines. Independent in-vivo evidence is more mixed than the marketing suggests, with the strongest effects observed at concentrations above 5% applied consistently for at least four weeks. In a finite 30-day ampoule cure with unpublished concentration, the realistic role of the peptide here is contributory rather than primary.

What distinguishes this formula in practical terms is the combination delivery: bakuchiol carried in a silicone-rich, fragrance-light vehicle that minimizes occlusion mismatch with other routine steps, alongside sodium hyaluronate for immediate optical plumping. The botanical 'cica' trio (Alchemilla, Hedera, Equisetum) functions less as evidence-based actives and more as a soothing botanical layer with traditional-use support; the heavier lifting is bakuchiol and the peptide. Lierac's choice to package as sealed ampoules also has formulation logic — bakuchiol is more stable than retinol but still benefits from light- and oxygen-restricted packaging — and is a meaningful detail when comparing this serum to identically labelled bakuchiol products sold in clear bottles.

References 1 ShowHide
  1. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. — British Journal of Dermatology (2019)

The clinical view

Dermatologists who treat patients flaring on retinoids often point to bakuchiol-based serums as a clinically reasonable bridge — useful when prescription retinoid tolerance fails, in pregnancy, or post-procedure when a recovery-friendly active is preferable. Lierac's pharmacy distribution in Europe means it shows up in dermatologists' practical recommendation lists there, although in U.S. clinics it is less ubiquitously cited than cult favorites like Tretinoin or over-the-counter retinol staples. The botanical 'cica' soothing layer is generally viewed as supportive but not the primary therapeutic mechanism, and dermatology educators tend to highlight that bakuchiol's published evidence supports modest improvement in fine lines and pigmentation rather than dramatic remodeling. Patients are usually advised to maintain daily broad-spectrum SPF regardless of bakuchiol's gentler profile, since photoprotection remains the single biggest contributor to long-term wrinkle outcomes.

Formula

Key ingredients

  1. Bakuchiol

    Sits high in this serum's INCI as the headline anti-wrinkle active. Bakuchiol modulates collagen-related pathways with a different mechanism than retinol, which is why Lierac chose it for a formula they wanted layerable in a morning routine — paired here with the silicone blend and hyaluronic acid, it gives wrinkle correction without the dryness retinol typically forces you to manage.

    Limited for Aging
  2. Acetyl Hexapeptide-8 (Argireline)

    Targets expression lines on the upper face — a smart pairing with bakuchiol's structural collagen support, because the two work on different wrinkle origins (motion vs. age-related laxity). The serum's gel-fluid base helps it sit on top of skin where the peptide can settle into fine lines around the eyes and forehead.

    Not yet assessed
  3. Sodium Hyaluronate

    The plumping humectant that Lierac counts on to deliver the immediate 'filler' visual effect this product is named for. In a 30-day ampoule cure, the cumulative hydration helps fine lines look softer day over day, while the soft-focus powders elsewhere in the formula add an optical blur effect on contact.

    Established mechanism for Dehydration · established mechanism
  4. Cica Botanical Complex (Alchemilla, Ivy, Horsetail)

    Lierac's house 'cica' shorthand here is actually a trio — Alchemilla Vulgaris, Hedera Helix, and Equisetum Arvense — chosen for soothing and tightening botanical activity rather than the classic Centella Asiatica madecassoside route. The mix calms reactive skin while bakuchiol does the active work, which is why this serum tends to be tolerated by people who normally flare on retinoids.

    Not yet assessed
  5. Tocopheryl Acetate (Vitamin E)

    Stabilizes the bakuchiol against oxidation and contributes a mild antioxidant layer in the ampoule. Because the ampoules are single-dose-style packaging, each fresh open delivers the vitamin E in good condition rather than the slowly oxidizing pot-jar reality most antioxidant serums suffer from.

    Limited for Aging
Full ingredient list 31 ingredients ShowHide

Aqua/Water/Eau, Propanediol, Dimethicone, PPG-1-PEG-9 Lauryl Glycol Ether, Ceteareth-30, Polyacrylate Crosspolymer-6, Alchemilla Vulgaris Leaf Extract, Bakuchiol, Dimethicone Crosspolymer, Dimethiconol, Hedera Helix (Ivy) Leaf/Stem Extract, Sodium Benzoate, Parfum/Fragrance, Sucrose Palmitate, Equisetum Arvense Extract, Citric Acid, Tetrasodium EDTA, Tocopheryl Acetate, Glyceryl Linoleate, Sodium Hyaluronate, Glycerin, Biosaccharide Gum-1, Yeast Extract/Extrait De Levure, Phenoxyethanol, Caprylyl Glycol, Glyceryl Caprylate, Sodium Anisate, Sodium Levulinate, Potassium Sorbate, Acetyl Hexapeptide-8, Ethylhexylglycerin

Safety & formulation facts

  • Pregnancy safe
  • Not fragrance free
  • Alcohol free
  • Oil free
  • Not silicone free
  • Paraben free
  • Sulfate free
  • Not cruelty free
  • Not vegan
  • Not fungal-acne safe
Potential irritants Parfum/Fragrance
Common allergens Parfum/Fragrance
Compatibility

Skin types & routine

Routine step serum
Time of day Morning & night
Best season All year
Finish satin, fast-absorbing, velvety

Layering

Lierac recommends a 30-day cure: empty one 10 ml ampoule over roughly ten days, applying morning and evening before moisturizer. The silicone-rich base settles best onto dry skin and pairs well under makeup. Skip the same routine slot as a high-strength retinoid — bakuchiol is gentler, but layering both adds redundant wrinkle-targeting without an obvious benefit.

When to expect results

Immediate optical blur from soft-focus powders and hyaluronic acid plumping on day one. After two to three weeks of consistent use, expression-line softening from the peptide activity becomes visible. The bakuchiol-driven collagen support typically asks for the full 30-day ampoule cure plus a few weeks beyond before structural improvement reads on camera.

Pairs well with niacinamidehyaluronic-acidceramidespeptides

A routine built around it

Morning

  1. Gentle cleanser
  2. Hydrating toner or essence
  3. Lierac Cica-Filler Anti-Wrinkle Repairing Serumthis product
  4. Moisturizer
  5. Broad-spectrum SPF 30+

Night

  1. Double cleanse
  2. Hydrating toner
  3. Lierac Cica-Filler Anti-Wrinkle Repairing Serumthis product
  4. Ceramide or rich moisturizer
Guidance

How to use it, and who it's for

How to use

Snap the seal on the first ampoule and use the supplied dropper or pipette to apply roughly four to five drops to a clean, dry face and neck, twice daily. Aim to finish each 10 ml ampoule across about ten days, completing the full three-ampoule course over thirty days. Apply after toner or essence and before moisturizer; the silicone-rich texture sits well under both daytime SPF and night creams. Pair morning use with a broad-spectrum SPF 30 or higher. Avoid stacking with a high-strength prescription retinoid in the same routine slot — alternate nights if you want to keep both. Reseal each opened ampoule with its cap between uses and finish within ten days of opening.

Is it worth the price?

Pricing is where this serum gets harder to defend without context. Roughly seventy U.S. dollars for 30 ml — split across three sealed ampoules — lands above CeraVe and even most Paula's Choice anti-aging serums on a per-millilitre basis. What you're paying for is the legacy French pharmacy lineage, the cure-format packaging, and a formulation built on actives with credible (if not retinoid-strength) evidence. The brand is established enough that this isn't paying for hype, but it is paying for prestige distribution. The most cost-rational way to run it is as a twice-yearly 30-day course paired with a less expensive bakuchiol or peptide moisturizer the rest of the year — that turns the spend into a defined investment rather than a perpetual subscription cost.

Who should buy it

People who responded poorly to retinol — flaking, redness, persistent dryness — but still want measurable softening of fine lines and expression wrinkles. Also a strong fit for those in pregnancy or post-procedure recovery (with their dermatologist's approval) who need a gentler structural-active and don't want to pause anti-aging entirely. The defined 30-day cure suits people who like results-driven, time-boxed routines.

Who should skip it

If you're already adapted to a tretinoin or higher-strength retinoid, this serum won't outperform what you have. Skip it if fragrance is a non-negotiable trigger for your rosacea or eczema, since it does contain parfum. Anyone looking for the cheapest bakuchiol on the market should look elsewhere — there are competent options at half the per-millilitre cost, even if they lack the ampoule packaging.

Ready to try it?Lierac Cica-Filler Anti-Wrinkle Repairing Serum · $69.00 · 30 ml (3 x 10 ml ampoules)
Details

The product, in detail

Texture
Gel-fluid that breaks to a silicone-soft slip when warmed between fingers — sits between a watery serum and a primer, leaving a faint blur on the surface.
Scent
A subtle floral-clean parfum that lingers briefly and then settles; noticeable on application, mostly gone within ten minutes.
Packaging
Three sealed 10 ml glass ampoules tucked in a paperboard sleeve — single-use-style dosing meant for a 30-day treatment cycle. Once snapped open, the ampoule is meant to be capped with the supplied dropper and finished over roughly ten days.
How long it lasts
About 30 days when used twice daily on face and neck — Lierac designs the format as a finite cure rather than an indefinite-use serum.
Once opened
Use within 6 months · track your toss-by date →
Size
30 ml (3 x 10 ml ampoules)
Made in
France
Launched
2018

What the first two weeks feel like

The first application is mostly a sensory event: a faint scent, a smoothing slip, and the soft-focus optical effect on contact. Nothing tingles or stings. Over the first ten to fourteen days, fine lines around the eyes and forehead read softer in good light. There is no purge phase — bakuchiol skips the retinization curve.

The story behind it

Why it exists

The Cica-Filler line was launched by Lierac in 2018 to extend the brand's longstanding wrinkle-correction franchise into the post-procedure and sensitive-skin space, where the brand's pharmacy audience increasingly demanded results-driven actives without retinoid downtime. The serum format followed the cream and has become Lierac's signature ampoule-cure offer abroad.

About Lierac Legacy Brand (20+ years)

Lierac was founded in 1975 in Paris by Dr. Henri Pinta, a plastic surgeon, and grew into one of France's pharmacy-distributed dermo-cosmetic staples. The brand has nearly five decades of formulation history and is widely carried in European pharmacies, though its English-language clinical publication footprint is smaller than that of giants like La Roche-Posay or Avène.

Brand founded 1975 · This product since 2018

Myth vs. reality

What people get wrong about it

MythBakuchiol is just a marketing rename for retinol.

RealityBakuchiol is a meroterpene extracted from Psoralea corylifolia and is structurally unrelated to retinoids. In this serum it modulates collagen synthesis through a different pathway, which is why the formula doesn't carry retinol's standard photosensitivity warning and skips the purge phase entirely.

MythAmpoules are stronger than regular serums.

RealityAmpoule packaging mostly protects the formula from oxidation and controls dosing; it doesn't raise active concentration. This serum's bakuchiol and peptide percentages aren't published, and the marketing benefit of ampoules here is freshness and cure discipline, not extra potency.

FAQ

Questions people ask

How is Lierac Cica-Filler Serum different from the cream version?

The serum runs the same bakuchiol-and-peptide direction as the cream but in a 30-day ampoule cure rather than an open-ended pot. The serum's texture is gel-fluid and silicone-rich for a soft-focus finish, while the cream is more moisturizing and leans on the same actives at a slower-release pace.

Can I use Lierac Cica-Filler Serum with retinol?

Technically yes, but it's redundant. Bakuchiol is doing similar wrinkle-targeting work to retinol with less irritation, so stacking the two adds risk without obvious benefit. If you're already on a stable retinoid routine, this serum makes more sense as a swap during sensitive periods than a co-add.

Is the Cica-Filler Serum pregnancy-safe?

The bakuchiol-based formulation here is generally considered acceptable during pregnancy — it does not contain retinoids, salicylic acid in treatment doses, or hydroquinone. The included fragrance is the main reason to clear it with your OB-GYN if you're fragrance-sensitive in pregnancy.

Why does the Lierac Cica-Filler Serum come in three 10 ml ampoules?

Lierac built this product around a 30-day treatment idea rather than a daily-forever serum. Each 10 ml ampoule covers about ten days of twice-daily application, and the sealed format keeps bakuchiol stable and oxidation-resistant between uses.

Will this Lierac serum work for crow's feet?

The Acetyl Hexapeptide-8 in the formula is specifically aimed at expression lines, including crow's feet and forehead lines. Expect noticeable softening over the 30-day cure rather than a same-week change, and pair it with consistent daily SPF for the effect to hold.

Does this serum contain fragrance?

Yes — there is parfum listed in the INCI. The scent is subtle and short-lived, but if you flag fragrance for rosacea or eczema, this isn't the bakuchiol serum to start with.

Reviews

What shoppers tend to say

Recurring themes our editors read across retailer reviews — summaries in our words, not quotations, and not a substitute for a patch test.

Common praise

  • Visible smoothing after the 30-day cure
  • Sinks in fast under makeup
  • Gentler than a retinol routine
  • Plump look on dehydrated fine lines

Common complaints

  • Price feels high for 30 ml total
  • Light fragrance bothers reactive users
  • Ampoule format can feel fussy day-to-day
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