The science
The 7.0 reframes anti-aging as stress biology, and its actives are chosen to match. Ergothioneine is the most interesting of them: a sulfur-containing amino acid derivative found in mushrooms that human cells import through a dedicated transporter, which is why it accumulates in tissues under oxidative load. A 2023 review in Molecules laid out its mechanisms in skin — direct radical scavenging, metal chelation and support of the cell's own antioxidant programme — and a 2024 study in Clinical, Cosmetic and Investigational Dermatology showed it protecting skin cells from UV-driven oxidative stress through the PI3K/AKT/Nrf2 pathway. Carnosine addresses a different insult: a 2018 study in Skin Pharmacology and Physiology found that a facial cream containing carnosine measurably inhibited the formation of advanced glycation end-products in human skin, the sugar-protein cross-links that stiffen collagen and give chronically stressed skin its yellowish tone. The two together are a coherent answer to what the box calls fatigue-induced aging.
Ectoin supplies the barrier arm. A 2022 systematic review in Dermatology and Therapy pooled the trials of topical ectoine in inflammatory conditions with impaired barrier function and found consistent improvements in hydration and barrier measures with an excellent safety profile, which supports its role here as the thing keeping a fragranced gel comfortable on depleted skin. Tranexamic acid's inclusion is the least expected: best known for melasma, it works by damping the plasmin-driven inflammatory signalling that stimulates melanocytes, and in a serum without exfoliants or vitamin C it is the mechanism behind the brightening claim.
The base is where the evidence is thinnest. Saccharomyces ferment filtrate and lysate are established humectant and conditioning ingredients with a plausible but largely company-generated literature, and Chando's HiMurchaSin data has not been published independently; the same is true of the palmitoyl tetrapeptide-10 at the end of the list. No trial of the finished 7.0 formula is available, so the science supports the design of the serum rather than the serum itself.
References 4 ShowHide
- Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin — Molecules (2023)
- Ergothioneine Protects Against UV-Induced Oxidative Stress Through the PI3K/AKT/Nrf2 Signaling Pathway — Clinical, Cosmetic and Investigational Dermatology (2024)
- Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin — Skin Pharmacology and Physiology (2018)
- Topical Ectoine Application in Children and Adults to Treat Inflammatory Diseases Associated with an Impaired Skin Barrier: A Systematic Review — Dermatology and Therapy (2022)