The science
The most defensible science in this cream is not the peptides but the hydration system built around them. The stratum corneum holds water with a mixture of free amino acids, pyrrolidone carboxylic acid and lactate — the natural moisturizing factor — and this formula reproduces most of it: sodium PCA, sodium lactate and eleven amino acids, placed above the peptides and below a sunflower-oil and shea lipid phase that slows water loss. That structure, humectants held under an occlusive lipid layer, is the mechanism every well-designed emollient cream relies on, and it explains why the cream keeps skin supple for hours despite absorbing in a minute.
The three peptides belong to the signal-peptide class. In their 2009 review in the International Journal of Cosmetic Science, Gorouhi and Maibach sorted topical anti-aging peptides into four groups — signal, enzyme-inhibitor, neurotransmitter-inhibitor and carrier — and assessed the controlled studies for each; signal peptides such as palmitoyl pentapeptide and the palmitoyl tripeptide and tetrapeptide fragments used here had the most supporting data, but the authors noted that much of it came from small, industry-sponsored trials. Palmitoyl tripeptide-5 is designed to mimic a thrombospondin fragment that activates TGF-beta, a pathway that upregulates collagen synthesis; palmitoyl tripeptide-1 imitates a collagen breakdown product that signals fibroblasts to rebuild matrix; and palmitoyl tetrapeptide-7 is reported to reduce interleukin-6 production, a cytokine associated with inflammatory collagen loss. Supplier studies of the tripeptide-1 and tetrapeptide-7 pair report improvements in wrinkle depth and skin roughness over two to three months at defined concentrations of the commercial blend; the concentration in this cream is undisclosed and, from its position in the list, likely below those tested levels.
The delivery matters. Palmitoylation — the fatty-acid tail on each peptide — improves penetration into the upper skin, and an oil-rich emulsion like this one is a favourable vehicle for lipophilic actives compared with a bare water gel. The tara gum film on top slows evaporation, which extends the window in which the peptides remain in contact with hydrated skin. None of this converts low-dose peptides into a retinoid; it does mean the cream is at least built in a way that gives them a chance.
References 1 ShowHide
- Role of topical peptides in preventing or treating aged skin — International Journal of Cosmetic Science (2009)