The science
The lotion's claim rests on two registered actives whose evidence is respectable and whose job is narrow. Dipotassium glycyrrhizate is the water-soluble salt of glycyrrhizin from licorice root, and licorice derivatives are among the best-supported botanical anti-inflammatories in dermatology; a 2010 evidence-based review of botanicals in the American Journal of Clinical Dermatology placed licorice among the plant extracts with credible anti-inflammatory and skin-calming data, and glycyrrhizate is a staple quasi-drug active in Japan for exactly the acne-and-rough-skin claim this product carries. Epsilon-aminocaproic acid is an antifibrinolytic amino acid, a close relative of tranexamic acid, that Japanese formulators use as an anti-inflammatory for irritated skin; its cosmetic literature is thin outside Japan, and its role here is best understood as a regulator-recognised partner to the glycyrrhizate rather than an independently evidenced active.
The botanicals are traditional with pockets of laboratory support. Coix seed, the adlay of the name, has a long East Asian record for rough skin and humectant polysaccharides but little clinical data in topical use. Houttuynia cordata has mouse-model studies in which its polysaccharides and fermentation products reduced atopic-dermatitis-type inflammation and barrier damage, reviewed comprehensively in Phytomedicine in 2024, without human trials of a cosmetic extract. Chamomile has a long anti-irritant record and is also a recognised, if uncommon, contact allergen.
The base is the clinically relevant part for anyone outside the target skin type. Ethanol at the levels a thin Japanese toner uses evaporates quickly and degreases the surface, which oily skin experiences as freshness and dry or compromised skin experiences as tightening and, with repeated use, barrier disruption. Menthol and camphor act on cold-sensing nerve receptors to produce the cooling sensation; the effect is sensory, not anti-inflammatory, and both are counter-irritants that can sting and worsen dermatitis on a damaged barrier, which is why they are discouraged on rosacea, eczema and post-procedure skin. The single sodium hyaluronate and trace of squalane soften the finish but do not offset the alcohol's drying on skin that lacks oil to spare. The formula is, in short, well matched to oily skin and mismatched to the sensitive skin the brand is known for.
References 2 ShowHide
- Botanicals in dermatology: an evidence-based review — American Journal of Clinical Dermatology (2010)
- Houttuynia Cordata Thunb.: A comprehensive review of traditional applications, phytochemistry, pharmacology and safety — Phytomedicine (2024)