ISDIN Isdinceutics Glicoisdin 8 Soft 50 g white jar with gold cap and box
Good choice for Rough Texture
What makes this different

Most glycolic products tell you the total acid percentage and nothing about how much is actually active. Glicoisdin 8 Soft publishes both the pH and the free-acid figure, 3.2% at pH 3.5 to 4, and pairs that gentle dose with borage oil and a ceramide in a cream base built for dry and sensitive faces rather than a watery toner. It is the entry point in a three-strength ladder that goes up to 25%.

ISDIN

ISDIN Isdinceutics Glicoisdin 8 Soft Exfoliating Peeling Cream Review

Beginner Glycolic Night Cream Exfoliants cream dermatologist recommended Paraben free Not cruelty free

A gentle, honest glycolic cream that tells you exactly how much acid is working, buffered to a strength dry and sensitive skin can use nightly and cushioned with borage oil. It is the right first rung on the glycolic ladder for mature skin, but the $85 jar is small, the base is too rich for oily faces, and it will not replace a retinoid.

Price $85.00 1.76 oz (50 g)
Shopper rating 4.8 ★★★★★ 200 reviews
On the market 2020 Made in Spain
Best for drynormal
Buy at Amazon ♥
Verdicts

How well it fits each concern

This assessment rests mainly on the glycolic acid literature and on the pH and free-acid figures ISDIN publishes for this cream, because its US review base is still modest at a couple of hundred across retailers despite several years on sale. The four-week luminosity claim comes from a brand consumer panel and has not been independently tested.

One verdict per concern. Open a row for the reasoning; the receipt has every source.

The scaleRecommendedGoodSupportingEarly evidenceNot for thisAvoidhow it works

Good choicefor Rough TextureGlycolic Acid is a reference standard by mechanism for rough texture; this cream carries it at 8%.Receipt2 sources on the row · 8% declared, studied range 4–10% · row checked Jul 17, 2026 · rule R5, same reading on 9,843 products · open the receipt

The case for it

  1. Glycolic Acid is a reference standard by mechanism for this concern — an established physical action, not a trial result.
  2. It is present at an effective concentration, declared or high in the ingredient list.
  3. The formula carries none of the triggers this concern is sensitive to.

Limited evidenceGentleNo reviews read yet

Same rule for everyone. “Good choice” is the verdict on 10,340 of 45,446 concern verdicts across the catalog; rule R5 decided 9,843 of them. Unchanged since September 25, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All rough texture products →How rough texture is treated →

Good choicefor DullnessGlycolic Acid is a reference standard by mechanism for dullness; this cream carries it at 8%.Receipt1 source on the row · 8% declared, studied range 4–10% · row checked Jul 17, 2026 · rule R5, same reading on 9,843 products · open the receipt

The case for it

  1. Glycolic Acid is a reference standard by mechanism for this concern — an established physical action, not a trial result.
  2. It is present at an effective concentration, declared or high in the ingredient list.
  3. The formula carries none of the triggers this concern is sensitive to.

Limited evidenceGentleNo reviews read yet

Same rule for everyone. “Good choice” is the verdict on 10,340 of 45,446 concern verdicts across the catalog; rule R5 decided 9,843 of them. Unchanged since September 25, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All dullness products →How dullness is treated →

Promisingfor AgingGlycolic Acid has trial-level evidence for aging but no guideline or regulatory standing yet — promising, short of a recommendation; the other actives here are not yet assessed for it.Receipt4 sources on the row · 8% declared, studied range 5–10% · row checked Jul 17, 2026 · rule R9p, same reading on 4,872 products · open the receipt

The case for it

  1. Glycolic Acid has at least one trial behind it for this concern but no guideline or regulatory standing yet.
  2. It is present at an effective concentration, declared or high in the ingredient list.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Moderate evidenceStandard tolerabilityNo reviews read yet

Cautions: a photosensitising active — use sun protection.

What would change this: Guideline or regulatory standing for the active on this concern would move this from a promising bet to a recommendation.

Same rule for everyone. “Promising” is the verdict on 4,872 of 45,446 concern verdicts across the catalog; rule R9p decided 4,872 of them. Unchanged since September 25, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All aging products →

Good choicefor DrynessCeramides is a reference standard by mechanism for dryness; this cream carries it.Receipt1 source on the row · row checked Jul 17, 2026 · rule R5, same reading on 9,843 products · open the receipt

The case for it

  1. Ceramide NP is a reference standard by mechanism for this concern — an established physical action, not a trial result.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries none of the triggers this concern is sensitive to.

Limited evidenceGentleNo reviews read yet

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Good choice” is the verdict on 10,340 of 45,446 concern verdicts across the catalog; rule R5 decided 9,843 of them. Unchanged since September 25, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All dryness products →

A verdict is Dermington’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.10-r231 · engine 5.2.0 · how we decide · this product’s receipt

Reader poll · Town SquareQuestion 1 of up to 3

Have you used Isdinceutics Glicoisdin 8 Soft Exfoliating Peeling Cream?

One tap counts. A couple of optional follow-ups come next.

No account neededOne answer each, change it any timeCounted only in anonymous totalsHow the Square counts →
Assessment

Pros & cons

What it does well 7

  • Publishes both pH and free-acid content, a rare honesty for a glycolic product
  • Buffered to 3.2% free acid so dry and sensitive skin can use it nightly
  • Fragrance-free and alcohol-free, with nothing irritating layered on top of the acid
  • Borage seed oil and a ceramide offset the drying effect of nightly exfoliation
  • Rich enough to replace a night cream on dry skin, saving a step
  • Noticeable smoothing within a few nights and brightening within two weeks
  • First rung of a clearly graduated range, so stepping up is straightforward

Where it falls short 6

  • $85 for a 50 g jar is steep for an entry-level glycolic cream
  • Heavy emollient base is too rich for oily or congestion-prone skin
  • Jar packaging means finger dipping and no dose control
  • Too gentle to move deeper lines or stubborn pigmentation
  • Ceramide NP is the last ingredient and closer to a label credit than a dose
  • Contains BHT, which some ingredient-conscious buyers avoid
Review

The full review

The most useful number on the Glicoisdin 8 Soft box is not the 8. It is the 3.2, printed smaller, which tells you how much of that glycolic acid is actually free to work at the cream's pH of 3.5 to 4. Most exfoliating products give you the total percentage and leave you to guess whether the formula has been neutralised into politeness or left sharp enough to sting. ISDIN publishes both figures, and the choice they encode is the whole personality of this product: enough active acid to do something every night, buffered enough that a dry, fifty-something face can keep doing it.

The range this belongs to has been sold in Spanish pharmacies for well over a decade, and the logic is a ladder. Glicoisdin 8 Soft is the bottom rung, a cream for dry, sensitive and mature skin; the 15 Moderate and 25 Intense are gels for people who have already adapted. ISDIN brought the ladder to the US around 2020 under its Isdinceutics label, and the 8 Soft has quietly gathered a few hundred mostly delighted reviews since, without the marketing weight the brand puts behind its sunscreens.

The formula is an old-fashioned emollient cream with an acid in it, and that is meant as a compliment. Water and glycolic acid lead, then PEG-100 stearate and glyceryl monostearate as emulsifiers, cetyl and stearyl alcohols for body, butylene glycol and glycerin for humectancy, and a run of isohexadecane, cetyl palmitate, two cyclic silicones and dimethicone for slip and cushion. Ammonium hydroxide is the neutraliser that brings the pH up from where 8% glycolic would naturally sit. Then comes the part that tells you who this is for: borage seed oil, the richest plant source of gamma-linolenic acid, and, at the very end of the list, ceramide NP. The ceramide is a gesture at that position, but the borage oil is real, and together they explain why a nightly acid cream can leave dry skin feeling supplied rather than scraped. There is no fragrance, no denatured alcohol and no essential oil, which for a product designed to be used on freshly exfoliated skin is exactly right. BHT as an antioxidant preservative is the one ingredient purists will object to; it is present in trace amounts to keep the borage oil from going off.

Using it is undramatic, which is the point. The cream is medium-thick, spreads easily and settles into a soft, velvety finish that reads as a night cream rather than a treatment. The first few evenings bring a brief tingle that fades within a minute, and if you follow ISDIN's advice to start on alternate nights, that is usually the extent of the adjustment. Skin feels noticeably smoother by the third or fourth application, the kind of glassy softness you get when the compacted outer layer of dead cells finally lets go. Within a couple of weeks the effect becomes visible as brightness, and over a month or two the tone evens and the fine lines around the mouth and eyes look shallower. ISDIN's own four-week panel reported unanimous improvement in luminosity, and while a brand panel is not a trial, that is a claim easy to believe for a well-made glycolic at this strength.

Where it disappoints is in what it cannot do. At 3.2% free acid this is an entry-level exfoliant, and anyone who has used a stronger glycolic or a retinoid will find it gentle to the point of subtle. It softens texture and brightens; it does not remodel deeper lines or clear stubborn pigmentation, and it should not be confused with the higher-strength products further up the same ladder. The base, so kind to dry skin, is a problem for oily and combination faces: cetyl palmitate, octyldodecanol and isocetyl alcohol make it rich enough that people prone to congestion will notice. The jar is the usual jar: fingers in the product, no dose control and a 50 g capacity that lasts two to three months at nightly use, which at $85 puts the monthly cost around $30 to $40 for a product doing one modest job.

The price is the honest sticking point. Glycolic acid is cheap, the emollient base is unremarkable, and the ingredient that lifts this above a drugstore AHA cream is really the formulation discipline, the published pH, the borage oil and the absence of anything irritating. That is worth something, particularly to people whose skin has reacted badly to sharper acids. It is not obviously worth double what comparable gentle glycolic creams cost, and there is no larger size to soften the arithmetic.

For its intended reader, a dry, mature or sensitive-skinned person who wants to start exfoliating nightly without the tightness and flaking that stronger products bring, Glicoisdin 8 Soft is a well-judged, trustworthy place to begin, and the clarity of its labelling makes it easy to know when you have outgrown it. For anyone with oily skin, an established acid tolerance or a budget, the same acid does the same work in cheaper and lighter forms.

The science

Glycolic acid is the smallest of the alpha-hydroxy acids, which lets it penetrate the stratum corneum more readily than lactic or mandelic acid, and its mechanism is well characterised: it reduces the cohesion between corneocytes at the lower layers of the stratum corneum, encouraging shedding of the compacted outer cells and speeding turnover. What separates one glycolic product from another is almost entirely how much acid is un-ionised and therefore able to penetrate, which is a function of pH. Glicoisdin 8 Soft contains 8% glycolic acid partially neutralised with ammonium hydroxide to pH 3.5 to 4, leaving 3.2% as free acid; that is a deliberately modest active dose, well below the 10 to 20% free-acid range used in dermatologist-applied superficial peels and designed for daily rather than periodic use.

The long-term case for daily low-strength AHAs comes from work such as the 1996 pilot study in the Journal of the American Academy of Dermatology, in which patients applied a 25% glycolic, lactic or citric acid lotion to one forearm and a placebo to the other for roughly six months. Treated skin showed an approximately 25% increase in thickness, with a thicker epidermis, increased dermal glycosaminoglycans, better-quality elastic fibres and denser collagen, and no inflammation on histology, the study's authors describing a significant reversal of epidermal and dermal markers of photoaging. That was a higher concentration than this cream delivers, so the dermal effects should be expected to be smaller and slower here, but the direction of the evidence supports the idea that consistent nightly use does more than polish the surface. A 2013 review in Clinical, Cosmetic and Investigational Dermatology covering glycolic acid across acne, scarring, melasma, post-inflammatory hyperpigmentation and photoaging notes that depth of effect scales with concentration, contact time and pH, and that the acid has a strong safety record in Fitzpatrick types I to IV.

The supporting cast is chosen to manage the acid's cost. Borage seed oil supplies gamma-linolenic acid, an omega-6 fatty acid with evidence for improving barrier function and reducing transepidermal water loss, which is the sensible counterweight to nightly desquamation; ceramide NP is present in trace quantity, and tocopheryl acetate contributes a mild antioxidant reserve. The claim that all panel participants saw more luminous skin at four weeks is from ISDIN's internal consumer study rather than an independent trial, and should be read as consistent with the glycolic literature rather than as evidence in its own right.

References 2 ShowHide
  1. Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study — Journal of the American Academy of Dermatology (1996)
  2. Glycolic acid peel therapy - a current review — Clinical, Cosmetic and Investigational Dermatology (2013)

The clinical view

Home glycolic products sit in a well-mapped corner of clinical practice: a low-strength, buffered AHA applied nightly is a standard suggestion for dull, rough or mildly photoaged skin in patients who either cannot tolerate a retinoid or want a complementary exfoliating step. What clinicians look for in such a product is exactly what this one publishes, a known pH and free-acid figure, because it lets them predict tolerance and advise on frequency instead of guessing. A 3.2% free acid cream in a fragrance-free emollient base is the sort of thing routinely recommended to dry and mature patients as a starting point, with the usual instructions to begin on alternate nights, pair it with daily broad-spectrum sunscreen, and keep it off the same evening as a retinoid. The main clinical caveats are that it is not a treatment for active acne, melasma or deeper rhytides, where stronger in-office peels or prescription agents do the work, and that the rich base makes it a poor match for seborrhoeic or acne-prone skin. Patients with rosacea, eczema or a recently compromised barrier are generally advised to hold off on any AHA until the skin is calm.

Formula

Key ingredients

  1. Glycolic Acid 8% total, 3.2% free acid

    Second in the list at 8% by weight, partially neutralised with ammonium hydroxide to a pH of 3.5 to 4 so that 3.2% remains as the free, active acid. That split is the whole design: enough bioavailable glycolic to loosen corneocyte bonds nightly, buffered so a dry or mature face can use it every evening rather than weekly.

    Established mechanism for Rough Texture · established mechanism
  2. Borago Officinalis Seed Oil

    Borage seed oil is the richest plant source of gamma-linolenic acid, and here it does the counter-work to the acid, replacing lipids that nightly exfoliation strips so the cream leaves skin supple rather than tight.

    Not yet assessed
  3. Ceramide NP

    The last ingredient in the list, so a token rather than a therapeutic dose, but its presence signals the formula's intent: a barrier lipid to offset the loosening effect of the glycolic acid in a cream aimed at dry and sensitive users.

    Established mechanism for Dryness · established mechanism
  4. Tocopheryl Acetate

    Provides a modest antioxidant cushion for skin whose stratum corneum is being thinned by the acid, and helps keep the borage oil from oxidising in the jar alongside the BHT.

    Limited for Aging
Full ingredient list 26 ingredients · pH 3.7 ShowHide

Water, Glycolic Acid, PEG-100 Stearate, Glyceryl Monostearate, Cetyl Alcohol, Stearyl Alcohol, Butylene Glycol, Isohexadecane, Cetyl Palmitate, Cyclopentasiloxane, Dimethicone, Glycerin, Ammonium Hydroxide, Phenoxyethanol, Cyclohexasiloxane, Borago Officinalis Seed Oil, Octyldodecanol, Sodium Carboxymethyl Cellulose, Xanthan Gum, Disodium EDTA, Ethylhexylglycerin, Glyceryl Polyacrylate, Tocopheryl Acetate, Isocetyl Alcohol, Butylated Hydroxytoluene (BHT), Ceramide NP

Safety & formulation facts

  • Pregnancy safe
  • Fragrance free
  • Alcohol free
  • Not oil free
  • Not silicone free
  • Paraben free
  • Sulfate free
  • Not cruelty free
  • Not vegan
  • Not fungal-acne safe
Pore-clogging (comedogenic) Cetyl PalmitateOctyldodecanolIsocetyl Alcohol
Potential irritants Glycolic AcidButylated Hydroxytoluene (BHT)
Common allergens Cetyl AlcoholStearyl Alcohol
Compatibility

Skin types & routine

Routine step treatment
Time of day Night
Best season All year
Finish velvety, satin

Layering

Apply at night to clean, dry skin as the treatment step, after eye cream and before or in place of a night cream. Skip retinoids and other acids on the nights you use it; a plain moisturizer on top is fine if skin feels tight.

When to expect results

Skin feels smoother after the first two or three nights and looks brighter within a couple of weeks as dead surface cells clear. Fine-line softening and a more even tone are four-to-eight-week outcomes, in line with ISDIN's own four-week luminosity panel.

Pairs well with sunscreenceramideshyaluronic-acid
Don't combine with retinolretinalsalicylic-acidbenzoyl-peroxide

A routine built around it

Morning

  1. Gentle cleanser
  2. Vitamin C serum
  3. Moisturizer
  4. Broad-spectrum SPF 50

Night

  1. Cleansing oil
  2. Gentle cleanser
  3. Eye cream
  4. ISDIN Isdinceutics Glicoisdin 8 Soft Exfoliating Peeling Creamthis product
Guidance

How to use it, and who it's for

How to use

Use in the evening on clean, dry skin. Apply eye cream first, then a pea-to-hazelnut amount of the cream to the face and, if you like, the neck, massaging until it disappears and avoiding the eye contour and lips. For the first week apply every other night, then nightly if your skin stays comfortable; a brief tingle on application is normal, persistent stinging or redness means you should go back to alternate nights. On dry skin no further moisturizer is usually needed, but a plain fragrance-free cream over the top is fine if the face feels tight by morning. Do not use it on the same night as a retinoid, salicylic acid or another exfoliant, and never on skin that is sunburnt, freshly waxed or recovering from a procedure. Because the acid increases sun sensitivity, broad-spectrum SPF every morning is not optional while using this product and for a week after stopping.

Is it worth the price?

Eighty-five dollars for 50 g is a premium price for what is, chemically, a modest dose of an inexpensive acid in a conventional emollient cream. The premium buys formulation discipline: a published pH and free-acid figure, a fragrance-free and alcohol-free base, borage oil and a ceramide to counter dryness, and the confidence of a pharmacy dermatology brand with a long track record in AHAs. On nightly use the jar lasts two to three months, so the cost runs roughly $30 to $40 a month; stretching to alternate nights, which many dry-skinned users settle into anyway, halves that. There is no larger size. For someone whose skin has reacted to cheaper, sharper glycolic products and who values a gentle, predictable nightly step that doubles as a night cream, the price is justifiable. For anyone comfortable with acids already, equivalent free-acid strength is available for far less.

Who should buy it

People with dry, normal or mildly sensitive skin who want to begin nightly exfoliation without the flaking and tightness of stronger acids, and mature skin looking for a gentle, fragrance-free step that improves texture and brightness while doubling as a night cream. Anyone who has been burned, literally, by a sharper glycolic toner will appreciate how predictable this one is.

Who should skip it

Oily, combination or acne-prone skin will find the emollient base too rich and should look at the gel versions in the same range. Experienced acid users will find the 3.2% free dose underwhelming, and anyone with active rosacea, eczema, a compromised barrier or recent cosmetic procedure should hold off on AHAs altogether until the skin has settled.

Ready to try it?ISDIN Isdinceutics Glicoisdin 8 Soft Exfoliating Peeling Cream · $85.00 · 1.76 oz (50 g)
Details

The product, in detail

Texture
A medium-thick white cream with a slight slip from the silicones, spreading easily and leaving a soft, cushioned feel rather than a film
Scent
Unscented; a faint, clean base-cream smell that disappears within seconds
Packaging
A squat white jar with a gold screw cap, boxed; the jar format means finger dipping and no dose control
How long it lasts
About two to three months of nightly face application from the 50 g jar; longer on an every-other-night schedule
Once opened
Use within 12 months · track your toss-by date →
Size
1.76 oz (50 g)
Made in
Spain
Launched
2020

What the first two weeks feel like

The first few nights bring a brief, mild tingle that fades in under a minute and a little tightness by morning if no moisturizer follows. ISDIN advises every-other-night use for the first week, and most skin is comfortable nightly after that. Light flaking is uncommon at this strength.

The story behind it

Why it exists

Glicoisdin has been a fixture in Spanish pharmacies for well over a decade, sold in graduated strengths so dermatologists could start patients low and step them up. ISDIN brought the range to the US around 2020 under the Isdinceutics banner, with the 8 Soft cream positioned as the version for dry, sensitive and mature skin that cannot tolerate the gel formats.

About ISDIN Legacy Brand (20+ years)

ISDIN is a Barcelona dermatology company founded in 1975 and co-owned by the Esteve pharmaceutical group, with a long pharmacy-channel record in Spain and Latin America. The Glicoisdin glycolic range has been a dermatologist-dispensed staple there for years; its US efficacy claims come from the brand's own four-week consumer panels.

Brand founded 1975 · This product since 2020

Myth vs. reality

What people get wrong about it

MythAn 8% glycolic acid cream is stronger than a 5% one, so it will exfoliate more.

RealityWhat matters is the free acid, which depends on pH. This cream is partially neutralised to pH 3.5 to 4, leaving 3.2% active glycolic, which is why it can be used nightly. An unbuffered 5% product at a lower pH could easily deliver more active acid than this.

MythGlycolic acid thins the skin over time.

RealityLong-term studies of daily AHA use on photoaged skin found the opposite: epidermal thickness increased and dermal collagen density improved. The acid removes the dead, compacted outer layer; it does not erode living tissue at cosmetic strengths.

FAQ

Questions people ask

How much glycolic acid is actually in Glicoisdin 8 Soft?

Eight percent by weight, of which 3.2% is free, active acid at the cream's pH of 3.5 to 4. The rest is neutralised with ammonium hydroxide, which is what makes a nightly schedule realistic for dry and sensitive skin.

Can I use Glicoisdin 8 Soft every night?

ISDIN suggests every other night for the first week and nightly after that if skin is comfortable. At 3.2% free acid most people tolerate nightly use, but if you notice persistent tightness or redness, drop back to alternate nights.

What is the difference between Glicoisdin 8 Soft, 15 Moderate and 25 Intense?

They form a ladder. The 8 Soft is a cream at 3.2% free glycolic for dry or sensitive skin; the 15 Moderate and 25 Intense are gel formats with progressively higher total and free acid, built for normal-to-oily skin that has already adapted to AHAs.

Do I need a moisturizer over Glicoisdin 8 Soft?

Often not. The base carries borage oil, cetyl and stearyl alcohols and a ceramide, so on normal or dry skin it can be the last step. If skin feels tight by morning, a simple fragrance-free moisturizer on top is fine.

Can Glicoisdin 8 Soft be used with retinol?

Not on the same night. Alternate them, glycolic one evening and retinol the next, or use the retinoid three nights a week and this cream on the others. Stacking both raises irritation without adding benefit.

Is Glicoisdin 8 Soft safe during pregnancy?

Glycolic acid at cosmetic strengths is generally considered acceptable in pregnancy, and the formula has no retinoids or fragrance. Skin can be more reactive during pregnancy, so start on alternate nights and confirm with your obstetrician.

Is Glicoisdin 8 Soft suitable for oily or acne-prone skin?

The acid is fine but the base is not: cetyl palmitate, octyldodecanol and isocetyl alcohol make it a rich cream. Oily skin does better with the gel versions in the same range.

Reviews

What shoppers tend to say

Recurring themes our editors read across retailer reviews — summaries in our words, not quotations, and not a substitute for a patch test.

Common praise

  • Smooth, softer skin within a week
  • Mild enough for nightly use without peeling
  • Rich texture doubles as a night cream on dry skin
  • No fragrance

Common complaints

  • Expensive for the jar size
  • Too rich for oily or combination skin
  • Mild tingling on first nights
  • Slow to show visible results on deeper lines
Notable endorsementsDispensed by dermatologists in Spain and Latin America as an entry-level home glycolicRecommended by dermatologists as a gentle nightly AHA for mature skin
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