The science
The gap between what this shampoo does and what it implies is a gap between leave-on and rinse-off, and the botanical literature makes the point. A 2019 overview in the Journal of Cosmetic Dermatology reviewed herbal alternatives in androgenetic alopecia, including saw palmetto, green tea, pumpkin seed, rosemary, grape seed and licorice, on the premise that these plants can inhibit 5-alpha-reductase and reduce the conversion of testosterone to dihydrotestosterone, the hormone that miniaturises follicles in pattern hair loss. The authors described the evidence as suggestive and the side-effect profile as milder than minoxidil or finasteride, and the studies they draw on are oral supplements and leave-on topicals with prolonged contact. Nothing in that literature supports a meaningful 5-alpha-reductase effect from two or three minutes of diluted contact in a shampoo, and saw palmetto's position twentieth in this list, at a fraction of a percent, does not change the arithmetic. ISDIN's instruction to leave the lather on the scalp is a reasonable attempt to extend contact but does not turn a wash into a treatment.
The ingredients that produce the shampoo's visible results are cosmetic and well understood. Zinc PCA is a sebum-regulating zinc salt with reasonable evidence for reducing scalp oiliness, which is why roots stay lifted; zinc gluconate adds a second, trace zinc source. The conditioning system is built on substantivity: laurdimonium hydroxypropyl hydrolyzed wheat protein, polyquaternium-10, polyquaternium-11, silicone quaternium-22 and hydrolysed soy protein are cationic or quaternised molecules that adsorb to the anionic surface of damaged hair and remain after rinsing, increasing the shaft's apparent diameter and reducing friction, which is the mechanism behind fuller-feeling, less breakage-prone fine hair. The surfactant system pairs sodium laureth sulfate with decyl glucoside, sodium cocoamphoacetate and cocamide DEA, a conventional blend that balances cleaning power against mildness; cocamide DEA is a recognised contact sensitiser in a minority of users. The B vitamins, amino acids and root extracts near the end of the list have no demonstrated topical effect on hair growth in a rinse-off, and biotin in particular is only useful orally in deficiency. ISDIN's eight-week panel measured self-reported perceptions of suitability, appearance and strength, consistent with the cosmetic mechanisms above, and did not report shedding or density outcomes.
References 1 ShowHide
- An overview of herbal alternatives in androgenetic alopecia — Journal of Cosmetic Dermatology (2019)