isoi Moisture Dr. Cream
Everything behind the verdicts on this product: the rule that fired for each concern, the three answers and the documents they rest on, every study on the row with the date it was opened, and the versions of the tables that produced them. Nothing here is edited by hand; it is generated from the same records the verdicts are.
The scaleRecommendedGoodSupportingEarly evidenceNot for thisAvoidhow it works
Engine 5.2.0 · rules 0.5.1 · evidence table ev-2026.10-r231 · computed October 13, 2026 · how we decide · the evidence table · the anchors
for Dehydration
Panthenol (Vitamin B5) is a reference standard by mechanism for dehydration; this cream carries it.
A trial-supported active, or a reference standard by mechanism, at a working level; or a first-line active below its studied range.
- Rule
- R5 → Good choice. A supported active (trial-backed, or a reference standard by mechanism); declared at a working strength, or a labelled active or at a plausible but undeclared level.
q1 = supported · q2 = adequate | plausible
Why this rule exists: Trial-supported or guideline-supported active, adequately or plausibly dosed.
Rule R5 decided 9,843 verdicts across the catalog; “Good choice” is the verdict on 10,340 of 45,446. The full register. - Carrying active
- Panthenol + Glycerin
- 1 · Standing
- Supported — its mechanism is established (a reference standard, not a trial result)
- 2 · Form
- Plausible — concentration not declared; read from the position in the ingredient list
Studied range: 2.5%, from the trials on the row; needs leave-on contact - 3 · Tolerability
- Standard tolerability
- Evidence dots
- Limited evidence
Row checked against its sources on July 17, 2026 (evidence table ev-2026.10-r231). - What readers report
- No reviews read yet for this product. Shown beside the verdict; never blended into it.
- Verdict since
- September 5, 2026 (unchanged across rebuilds since then)
The studies and documents on the row
- Cosmetic Ingredient Review assessment of panthenol / dexpanthenol — humectant and moisturizer that raises stratum-corneum water content — reference work
← Back to the verdict All dehydration products → Disclose a concentration or correct a fact →
for Sensitivity
This formula carries fragrance — the kind of thing reactive skin flags first.
The formula carries a known trigger for the concern — fragrance for rosacea, comedogenic esters for acne, fungal triggers for fungal acne — which decides the verdict before any efficacy question.
- Rule
- F1 → Avoid. The formula carries a known trigger for the concern.
q3 = harsh
Why this rule exists: Sensitivity has no efficacy claim; the verdict is tolerability.
Rule F1 decided 605 verdicts across the catalog; “Avoid” is the verdict on 1,912 of 45,446. The full register. - Carrying active
- Panthenol + Glycerin
- 1 · Standing
- Not assessed
No evidence row exists for this active and concern; it is in the research queue. - 2 · Form
- Plausible — concentration not declared; read from the position in the ingredient list
- 3 · Tolerability
- Carries a trigger — fragrance load
- Evidence dots
- Not from a trial row
- What readers report
- No reviews read yet for this product. Shown beside the verdict; never blended into it.
- Verdict since
- September 5, 2026 (unchanged across rebuilds since then)
← Back to the verdict All sensitivity products → Disclose a concentration or correct a fact →
for Compromised Skin Barrier
This formula carries fragrance — a known trigger for compromised skin barrier — so it is not a fit however good its actives are.
The formula carries a known trigger for the concern — fragrance for rosacea, comedogenic esters for acne, fungal triggers for fungal acne — which decides the verdict before any efficacy question.
- Rule
- R1 → Avoid. The formula carries a known trigger for the concern.
q3 = harsh
Why this rule exists: Safety outranks praise (MASTER-PLAN §1.7). A condition-weighted trigger (multiplier ≥ 2 in condition-fit-matrix) decides the verdict before any efficacy question.
Rule R1 decided 1,307 verdicts across the catalog; “Avoid” is the verdict on 1,912 of 45,446. The full register. - Carrying active
- Ceramide NP + Phytosphingosine
- 1 · Standing
- Supported — its mechanism is established (a reference standard, not a trial result)
- 2 · Form
- Plausible — concentration not declared; read from the position in the ingredient list
Studied range: 0.5–1%, from the trials on the row; needs leave-on contact; judge it after about 4 weeks - 3 · Tolerability
- Carries a trigger — fragrance load
- Evidence dots
- Limited evidence
Row checked against its sources on July 17, 2026 (evidence table ev-2026.10-r231). - What readers report
- No reviews read yet for this product. Shown beside the verdict; never blended into it.
- Verdict since
- September 5, 2026 (unchanged across rebuilds since then)
The studies and documents on the row
- Elias PM, Skin Barrier / Coderch et al., ceramides and skin barrier function — ceramides ~50% of SC intercellular lipid mass, essential to the permeability barrier — reference work
← Back to the verdict All compromised skin barrier products → Disclose a concentration or correct a fact →
for Dryness
Ceramides is a reference standard by mechanism for dryness; this cream carries it.
A trial-supported active, or a reference standard by mechanism, at a working level; or a first-line active below its studied range.
- Rule
- R5 → Good choice. A supported active (trial-backed, or a reference standard by mechanism); declared at a working strength, or a labelled active or at a plausible but undeclared level.
q1 = supported · q2 = adequate | plausible
Why this rule exists: Trial-supported or guideline-supported active, adequately or plausibly dosed.
Rule R5 decided 9,843 verdicts across the catalog; “Good choice” is the verdict on 10,340 of 45,446. The full register. - Carrying active
- Ceramide NP + Phytosphingosine
- 1 · Standing
- Supported — its mechanism is established (a reference standard, not a trial result)
- 2 · Form
- Plausible — concentration not declared; read from the position in the ingredient list
- 3 · Tolerability
- Standard tolerability — fragrance load
Cautions: fragrance. - Evidence dots
- Limited evidence
Row checked against its sources on July 17, 2026 (evidence table ev-2026.10-r231). - What readers report
- No reviews read yet for this product. Shown beside the verdict; never blended into it.
- Verdict since
- September 5, 2026 (unchanged across rebuilds since then)
The studies and documents on the row
- Elias PM, Feingold KR (eds), Skin Barrier — stratum corneum ceramides are the principal intercellular lamellar lipid; their depletion is the biochemical signature of dry/xerotic skin — reference work
← Back to the verdict All dryness products → Disclose a concentration or correct a fact →
for Acne
Nothing here targets acne directly; barrier care alongside acne treatment is the recognised companion to treating it, and this cream does that without known triggers.
Nothing here targets the concern directly, but the product’s job — barrier care, gentle cleansing, photoprotection — is the recognised companion to treating it. Rinse-off products carrying leave-on actives land here too.
- Rule
- R8 → Supporting role. An active with early or mechanistic evidence only or an active researched for the concern and found wanting or an active with no evidence row for the concern yet; the product’s category job is a recognised companion to treating the concern.
q1 = plausible | none | not-assessed · supportive = true
Why this rule exists: The category's job (barrier care, humectant hydration, gentle cleansing, photoprotection) is the documented supportive role for this concern. This is the honest verdict for a moisturizer on an acne page.
Rule R8 decided 3,793 verdicts across the catalog; “Supporting role” is the verdict on 7,796 of 45,446. The full register. - Carrying active
- Panthenol + Glycerin
- 1 · Standing
- Not assessed
No evidence row exists for this active and concern; it is in the research queue. - 2 · Form
- Plausible — concentration not declared; read from the position in the ingredient list
- 3 · Tolerability
- Standard tolerability — fragrance load
Cautions: fragrance. - Evidence dots
- Not from a trial row
- What readers report
- No reviews read yet for this product. Shown beside the verdict; never blended into it.
- Verdict since
- September 5, 2026 (unchanged across rebuilds since then)
← Back to the verdict All acne products → Disclose a concentration or correct a fact →
as a moisturizer
Does what a moisturizer is for: supplies barrier lipids, draws in water.
- Rule
- J2 → Does the job. The category-job reading is 65 or more.
Category job score over the measured features 65–85. - Measured from the label
- draws in water, softens and smooths, seals moisture in, supplies barrier lipids, right weight for the job
- Tolerability
- Standard tolerability
Listed for Excess Oiliness, with no verdict: the actives here have no evidence row for that concern yet. That is a gap in our table, not a mark against the product.
- Excess Oiliness: The actives here (Panthenol (Vitamin B5), Ceramides, Hyaluronic Acid, Tea Tree Oil) are in the research queue for excess oiliness; no verdict until their rows are written.
- Fragrance
A verdict is Dermington’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Every rule is public and the same for every product; a brand cannot buy a reading. How we decide · what has changed · disclaimer.