Rejuran Derma Healer Pore Tightening Ampoule dropper bottle, a K-beauty leave-on multi-acid pore treatment with niacinamide, polynucleotide, and witch hazel
Promising for Large Pores
What makes this different

It packs five exfoliating acids across AHA, BHA, PHA, and LHA into a leave-on ampoule, buffered with niacinamide, soothing botanicals, and the brand's polynucleotide for a continuous, targeted pore treatment. The trade-off that sets it apart, not always for the better, is the addition of bergamot, grapefruit, and lavender essential oils for scent.

Rejuran

Rejuran Derma Healer Pore Tightening Ampoule Review

Potent Pore Ampoule Spot Treatments ampoule k beauty Paraben free Not cruelty free

A potent leave-on pore treatment stacking five exfoliating acids with niacinamide, witch hazel, and the brand's polynucleotide — genuinely effective at smoothing texture and refining the look of pores on resilient, oily skin. The avoidable flaw is the addition of bergamot, grapefruit, and lavender oils, which make an already acid-heavy product more irritating and photosensitizing than it needed to be. Strong, but not for sensitive skin.

Price $34.00 1.01 fl oz / 30ml
Shopper rating 4.2 ★★★★★ 150 reviews
On the market 2024 Made in South Korea
Buy at Amazon ♥
Verdicts

How well it fits each concern

A recent launch with a modest independent review base and limited clinical testing, this ampoule is judged on its well-evidenced exfoliating acids and niacinamide, balanced against the irritation and phototoxicity risk of its witch hazel and citrus and lavender oils. The brand's polynucleotide claim draws on emerging topical evidence and is weighted as a soothing addition rather than a proven driver.

One verdict per concern. Open a row for the reasoning; the receipt has every source.

The scaleRecommendedGoodSupportingEarly evidenceNot for thisAvoidhow it works

Promisingfor Large PoresNiacinamide has trial-level evidence for large pores but no guideline or regulatory standing yet — promising, short of a recommendation; the other actives here are not yet assessed for it.Receipt3 sources on the row · concentration not declared; studied range 4% · row checked Jul 17, 2026 · rule R9p, same reading on 4,872 products · open the receipt

The case for it

  1. Niacinamide has at least one trial behind it for this concern but no guideline or regulatory standing yet.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Moderate evidenceStandard tolerabilityNo reviews read yet

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Promising” is the verdict on 4,872 of 45,446 concern verdicts across the catalog; rule R9p decided 4,872 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All large pores products →

Promisingfor Excess OilinessNiacinamide has trial-level evidence for excess oiliness but no guideline or regulatory standing yet — promising, short of a recommendation; the other actives here are not yet assessed for it.Receipt2 sources on the row · concentration not declared; studied range 2% · row checked Jul 17, 2026 · rule R9p, same reading on 4,872 products · open the receipt

The case for it

  1. Niacinamide has at least one trial behind it for this concern but no guideline or regulatory standing yet.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Moderate evidenceStandard tolerabilityNo reviews read yet

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Promising” is the verdict on 4,872 of 45,446 concern verdicts across the catalog; rule R9p decided 4,872 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All excess oiliness products →

Strong choicefor BlackheadsSalicylic Acid is an approved or monograph active for blackheads; this ampoule carries it, though the concentration is not declared.Receipt21 CFR § 333.350 - Labeling of acne drug products. (opened Jul 27, 2026) · concentration not declared; studied range 0.5–2% · row checked Jul 27, 2026 · rule R3, same reading on 570 products · open the receipt

The case for it

  1. Multi-Acid Complex is an approved or monograph active for this concern.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Moderate evidenceStandard tolerabilityNo reviews read yet

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Strong choice” is the verdict on 1,475 of 45,446 concern verdicts across the catalog; rule R3 decided 570 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All blackheads products →How blackheads is treated →

Good choicefor Rough TextureSalicylic Acid is a reference standard by mechanism for rough texture; this ampoule carries it.Receipt2 sources on the row · concentration not declared; studied range 0.5–2% · row checked Jul 17, 2026 · rule R5, same reading on 9,843 products · open the receipt

The case for it

  1. Multi-Acid Complex is a reference standard by mechanism for this concern — an established physical action, not a trial result.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Limited evidenceStandard tolerabilityNo reviews read yet

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Good choice” is the verdict on 10,340 of 45,446 concern verdicts across the catalog; rule R5 decided 9,843 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All rough texture products →How rough texture is treated →

Strong choicefor AcneSalicylic Acid is an approved or monograph active for acne; this ampoule carries it, though the concentration is not declared.Receipt§ 333.310 Acne active ingredients. (opened Jul 27, 2026) · concentration not declared; studied range 0.5–2% · row checked Jul 27, 2026 · rule R3, same reading on 570 products · open the receipt

The case for it

  1. Multi-Acid Complex is an approved or monograph active for this concern.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Moderate evidenceStandard tolerabilityNo reviews read yet

Cautions: fragrance; known irritants.

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Strong choice” is the verdict on 1,475 of 45,446 concern verdicts across the catalog; rule R3 decided 570 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All acne products →How acne is treated →

A verdict is Dermington’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.10-r231 · engine 5.2.0 · how we decide · this product’s receipt

Reader poll · Town SquareQuestion 1 of up to 3

Have you used Derma Healer Pore Tightening Ampoule?

One tap counts. A couple of optional follow-ups come next.

No account neededOne answer each, change it any timeCounted only in anonymous totalsHow the Square counts →
Assessment

Pros & cons

What it does well 6

  • Potent five-acid blend for pores and texture
  • Oil-soluble BHA and LHA penetrate into pores
  • Niacinamide regulates oil and adds brightening
  • Soothing botanicals and polynucleotide buffer the acids
  • Sustained leave-on action for targeted pore care
  • Effective and visible on resilient, oily skin

Where it falls short 5

  • Bergamot, grapefruit, and lavender oils add irritation and phototoxicity
  • Five acids plus witch hazel are harsh for many
  • Too active and fragranced for sensitive or dry skin
  • Demands strict daily sunscreen
  • Brand's own fragrance-free pad is often the smarter choice
Review

The full review

Some formulas tell a clear story; this one tells two, and they contradict each other. On one hand, the Rejuran Pore Tightening Ampoule is a serious, clinical-feeling pore treatment from a brand rooted in medical aesthetics — a leave-on stack of well-chosen exfoliating acids buffered with soothing actives. On the other, that same ingredient list ends with bergamot oil, grapefruit peel oil, and lavender oil, three fragrant essential oils that work directly against everything the rest of the formula is trying to do. Reviewing it honestly means holding both stories at once and deciding whether the good outweighs the self-inflicted.

Start with the genuinely good, because the active core is strong. This packs five exfoliating agents spanning the full toolkit: glycolic and lactic acids (AHAs) for surface resurfacing, salicylic and capryloyl salicylic acids (BHA and the oil-loving LHA) to get inside sebum-filled pores, and gluconolactone (a gentle PHA), plus willow bark for good measure. As a leave-on ampoule rather than a swipe-off pad, that exfoliation is sustained, which makes it more potent and targeted — genuinely effective at clearing pores, smoothing texture, and reducing the look of congestion on skin that can handle it. Niacinamide sits high to regulate oil, support the barrier, and add brightening, and Rejuran's signature hydrolyzed DNA polynucleotide is included for a soothing, recovery-supportive role. Soothing botanicals — oat, calendula, allantoin — and a touch of copper and amino acids round it out. On paper, the buffered multi-acid approach is smart, and for resilient oily and combination skin chasing pore and texture refinement, it works.

Now the contradiction. Witch hazel, while useful as a pore astringent, is an irritant for some. And then there are the essential oils. Bergamot and grapefruit are citrus oils with well-documented phototoxic potential, and lavender oil is a common sensitizer. Putting these into a leave-on product that already contains five exfoliating acids is genuinely puzzling: you've built something that increases sun sensitivity through the acids, then added citrus oils that increase it further, in a treatment that demands the user already be diligent with sunscreen. For a brand whose entire identity is clinical, recovery-focused skincare, the fragrance choice reads as a marketing decision overriding a formulation one. It doesn't ruin the product, but it meaningfully narrows who can safely use it and adds risk that a fragrance-free version — like the brand's own pore pad — simply doesn't carry.

In use, the experience reflects both sides. It's a lightweight, watery ampoule that absorbs fast and leaves skin smooth and de-greased, with a noticeable citrus-herbal scent. A mild acid tingle is normal. On resilient skin used a few nights a week, it delivers visibly smoother, less shiny skin and gradual pore-and-texture improvement over a month or two. On less resilient skin, the five-acid-plus-witch-hazel-plus-citrus-oil combination tips quickly into stinging, dryness, or worse.

That leads to the firm usage guardrails, which matter more here than for most products. This is a few-nights-a-week treatment, not a daily one, applied thinly to pore-prone areas rather than slathered over the whole face. Don't stack it with a retinoid or another exfoliant the same night. Always follow with a barrier moisturizer. And be religious about daytime sunscreen — between the acids and the citrus oils, skipping it is asking for irritation or pigmentation. Sensitive, rosacea-prone, dry, or barrier-compromised skin should skip it entirely; this is a product for oily, resilient complexions only.

Value is middling. At around thirty-four dollars for 30ml, it's reasonable for a potent multi-acid leave-on with the polynucleotide and clinical pedigree, lasting a couple of months at sensible use. But the value calculus is undercut by the essential oils, because the brand's own fragrance-free pore pad offers much of the same multi-acid benefit at a similar price with far less risk — which makes it hard to recommend this version over that one for most people.

It's worth naming why the essential-oil choice is so frustrating specifically here, rather than just noting it as a generic con. Citrus oils like bergamot and grapefruit contain furocoumarins, compounds with documented phototoxic potential — they can make skin react badly to sun exposure. Pair that with a stack of five exfoliating acids, which already thin the stratum corneum and raise photosensitivity, and you've doubled down on the exact risk the product most needs to avoid. A clinical brand building a serious pore treatment had every reason to leave fragrance out, and its own pad proves it knows how. Including phototoxic citrus oils in this particular formula isn't just a neutral fragrance preference; it's actively working against the product's own purpose, which is what makes it more than a minor quibble.

The verdict, then, is genuinely mixed in a way most products aren't. The actives are strong and the formula is, at its core, a well-built pore treatment that delivers real results for the right skin. But the bergamot, grapefruit, and lavender oils are an unforced error that adds irritation and photosensitivity to an already demanding product, and they're the reason this lands as a qualified recommendation rather than an enthusiastic one. If your skin is oily and resilient, you're diligent with sunscreen, and you specifically want a potent leave-on pore ampoule, it can work well. For almost everyone else — and certainly for anyone fragrance-sensitive — the brand's fragrance-free pad is the smarter buy, and the existence of that better-judged sibling is the most damning thing about this ampoule.

The science

The active core rests on solid exfoliation science. Glycolic and lactic acids (AHAs) resurface the skin's surface; salicylic acid (BHA) and capryloyl salicylic acid (LHA) are lipophilic and penetrate sebum-filled pores, the mechanism most relevant to refining pore appearance and clearing congestion; gluconolactone (PHA) and willow bark add gentler exfoliation. Niacinamide is well-evidenced for sebum regulation and barrier support, complementing the pore goal and helping offset acid dryness. The concern is the additive profile: witch hazel can be irritating, and bergamot and grapefruit oils contain furocoumarins with documented phototoxic potential, while lavender oil is a recognized sensitizer — combining these with five acids in a leave-on product compounds both irritation and photosensitivity. The hydrolyzed DNA (polynucleotide) is Rejuran's signature, with emerging rather than established topical evidence, functioning as a soothing addition. No topical permanently reduces pore diameter; the benefit is from clearing and de-oiling pores. The fair scientific summary is a genuinely effective multi-acid pore treatment whose formulation merit is undercut by avoidable photosensitizing fragrance ingredients, making diligent sun protection and careful use essential.

The clinical view

Leave-on multi-acid treatments are generally regarded in clinical contexts as effective for refining the appearance of pores, texture, and oiliness on resilient skin, with the caveat that sustained acid exposure raises the risk of irritation and barrier disruption if overused. Clinicians typically advise limited frequency, avoidance of stacking with other exfoliants or retinoids, and rigorous daily sun protection. The inclusion of citrus essential oils such as bergamot and grapefruit is commonly flagged as a concern, since their furocoumarin content carries phototoxic potential, which is compounded in an acid-containing leave-on product; lavender oil is likewise a recognized sensitizer. Such formulations are considered unsuitable for sensitive, rosacea-prone, dry, or barrier-compromised skin, and salicylic acid content is often limited during pregnancy. Overall it is viewed as a potent option for oily, resilient skin used carefully, with fragrance-free alternatives preferred where available.

Formula

Key ingredients

  1. Multi-Acid Complex (Glycolic/AHA, Salicylic/BHA, Gluconolactone/PHA, Capryloyl Salicylic/LHA, Willow Bark)

    A leave-on blend of five exfoliating agents across AHA, BHA, PHA, and LHA does the pore-refining and texture work continuously, with the oil-soluble salicylic and capryloyl salicylic acids clearing pores while glycolic and lactic acids resurface — a more sustained, and more potentially irritating, exfoliation than a quick swipe-off pad.

    Established mechanism for Rough Texture · established mechanism
  2. Niacinamide

    Niacinamide regulates oil and supports the barrier, reinforcing the pore goal and helping buffer the multi-acid load, while adding the brightening side of the ampoule's 'double functional' brightening-and-wrinkle claim.

    Limited for Large Pores
  3. Hydrolyzed DNA (c-PDRN)

    Rejuran's signature polynucleotide is included for a soothing, recovery-supportive role meant to offset the exfoliating acids; its topical evidence is emerging, but it fits the brand's attempt to make a gentler, conditioning acid treatment.

    Not yet assessed
  4. Witch Hazel + Soothing Botanicals (Calendula, Oat, Allantoin)

    Witch hazel adds astringent, pore-refining action while calendula, oat, and allantoin calm — an attempt to keep the acid ampoule comfortable, though the witch hazel and the added citrus and lavender oils pull in the opposite, more irritating direction.

    Not yet assessed
Full ingredient list 41 ingredients ShowHide

Water, Butylene Glycol, Glycerin, Aloe Barbadensis Leaf Juice, Cucumis Sativus (Cucumber) Fruit Extract, Niacinamide, 1,2-Hexanediol, Hamamelis Virginiana (Witch Hazel) Extract, Gluconolactone, Lactic Acid, Hydrolyzed DNA, Dipropylene Glycol, Caprylic/Capric Triglyceride, Glycolic Acid, Sodium Hydroxide, Sodium Hyaluronate, Xanthan Gum, Avena Sativa (Oat) Kernel Extract, Calendula Officinalis Extract, Propanediol, Caramel, White Willow Bark Extract, Laminaria Ochroleuca Extract, Salicylic Acid, Allantoin, Disodium EDTA, Ethylhexylglycerin, Acacia Senegal Gum, Adenosine, Pentylene Glycol, Sodium Mannose Phosphate, Mannose, Lysine, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Lavandula Angustifolia (Lavender) Oil, Proline, Copper Sulfate, Achillea Millefolium Extract, Capryloyl Salicylic Acid, Citrus Paradisi (Grapefruit) Peel Oil

Safety & formulation facts

  • Pregnancy safety unverified
  • Not fragrance free
  • Alcohol free
  • Not oil free
  • Silicone free
  • Paraben free
  • Sulfate free
  • Not cruelty free
  • Not vegan
  • Not fungal-acne safe
Potential irritants Glycolic AcidSalicylic AcidLactic AcidCapryloyl Salicylic AcidWitch Hazel ExtractBergamot Fruit OilGrapefruit Peel OilLavender Oil
Common allergens Bergamot Fruit OilLavender OilGrapefruit Peel Oil
Compatibility

Skin types & routine

Routine step treatment
Time of day Night
Best season fall & winter
Finish lightweight, fast-absorbing, non-greasy

Layering

Use it at night a few times a week, after cleansing and toner, applying a thin layer to pore-prone areas before moisturizer rather than over the whole face daily. Don't pair it with a retinoid or other exfoliants the same night, follow with a barrier moisturizer, and wear sunscreen diligently the next day, since both the acids and the citrus oils raise sun sensitivity.

When to expect results

Skin looks smoother and shine is reduced fairly quickly; pore appearance and texture improve over four to eight weeks of consistent, sensible use, assuming the skin tolerates the acids and added oils without irritation.

Pairs well with tonermoisturizer
Don't combine with retinoidexfoliant

A routine built around it

Morning

  1. Cleanser
  2. Toner
  3. Niacinamide Serum
  4. Moisturizer
  5. SPF

Night

  1. Cleanser
  2. Toner
  3. Rejuran Derma Healer Pore Tightening Ampoulethis product
  4. Moisturizer
Guidance

How to use it, and who it's for

How to use

Use it at night, a few times a week rather than daily, after cleansing and toner. Apply a thin layer to pore-prone areas like the nose, chin, and forehead rather than the whole face, and follow with a barrier moisturizer. Don't combine it with retinoids or other exfoliants the same night, and ease in slowly to gauge tolerance. Wear sunscreen every morning without fail, since both the acids and the citrus oils increase sun sensitivity.

Is it worth the price?

At around $34 for 30ml, this is reasonably priced for a potent leave-on multi-acid treatment with niacinamide, the polynucleotide, and clinical-brand pedigree, and a thin few-times-weekly application makes the bottle last a couple of months. The value is undercut, though, by the essential oils: Rejuran's own fragrance-free pore pad delivers much of the same multi-acid benefit at a comparable price with far less irritation and photosensitivity risk, which makes it the better buy for most people. The ampoule's value is genuine only for resilient, oily skin that specifically wants a stronger, targeted leave-on format and tolerates the citrus and lavender oils. For everyone else, the same money is better spent on a fragrance-free alternative.

Who should buy it

Oily and combination skin with a resilient barrier that wants a potent, targeted leave-on treatment for the look of pores, texture, and congestion, and that tolerates exfoliating acids and fragrance. Best for those who are diligent with daily sunscreen and want stronger pore care than a swipe-off pad.

Who should skip it

Sensitive, rosacea-prone, dry, or barrier-compromised skin should avoid the acid load and the citrus and lavender oils, as should anyone fragrance-sensitive or unwilling to commit to daily sunscreen. Pregnancy is a reason to be cautious with the salicylic acid. Most of these users are better served by the brand's fragrance-free pore pad.

Ready to try it?Rejuran Derma Healer Pore Tightening Ampoule · $34.00 · 1.01 fl oz / 30ml
Details

The product, in detail

Texture
A lightweight, watery ampoule that absorbs quickly with a clean, slightly astringent finish
Scent
Has a noticeable citrus-herbal scent from the bergamot, grapefruit, and lavender oils
Packaging
Small dropper bottle for targeted, measured application
How long it lasts
Around 2-3 months with a few-times-weekly thin application from the 30ml bottle
Once opened
Use within 12 months · track your toss-by date →
Size
1.01 fl oz / 30ml
Made in
South Korea
Launched
2024

What the first two weeks feel like

It absorbs quickly and leaves skin feeling smooth and de-greased, with a perceptible citrus-herbal scent from the essential oils. A mild tingle from the acids is normal; ease in slowly, since the five-acid blend plus witch hazel and citrus oils can tip into stinging or dryness on less resilient skin.

The story behind it

Why it exists

Rejuran extended its Derma Healer pore line into a leave-on ampoule for more intensive, targeted pore care than its swipe-off pad, keeping the polynucleotide-and-soothing approach. The inclusion of citrus and lavender oils reflects a fragrance choice at odds with the otherwise clinical, recovery-focused positioning.

About Rejuran Established Brand (5–20 years)

Rejuran is the skincare arm of Korea's PharmaResearch, maker of the well-known Rejuran PDRN aesthetic injectables, giving it real clinical credibility in polynucleotide science. This leave-on pore ampoule pairs a multi-acid blend with the brand's hydrolyzed DNA; independent studies on the topical product are limited, but the brand has an established footprint.

Brand founded 2014 · This product since 2024

Myth vs. reality

What people get wrong about it

MythA stronger, leave-on acid product will shrink pores faster than a rinse-off one.

RealityA leave-on ampoule does give more sustained exfoliation, but 'faster' often just means 'more irritating.' Pores look smaller from being cleared and de-oiled, not shrunk, and over-doing acids damages the barrier, which makes skin look worse. Consistency and restraint beat intensity here.

FAQ

Questions people ask

What acids are in the Rejuran Pore Tightening Ampoule?

It contains five exfoliating agents: glycolic acid (AHA), lactic acid (AHA), salicylic acid (BHA), capryloyl salicylic acid (LHA), and gluconolactone (PHA), plus willow bark. Because it's a leave-on ampoule, that exfoliation is more sustained and more potentially irritating than a quick swipe-off pad.

Does the Rejuran pore ampoule contain fragrance or essential oils?

Yes — it includes bergamot fruit oil, grapefruit peel oil, and lavender oil. These citrus oils in particular can be photosensitizing and irritating, which is a notable drawback in an already acid-heavy leave-on product, so sensitive skin should be cautious and everyone should be diligent with sunscreen.

Is the Rejuran Pore Ampoule good for sensitive skin?

Not really. Despite soothing additions like niacinamide, oat, and the brand's polynucleotide, the combination of five acids, witch hazel, and citrus and lavender oils makes it too active and fragranced for sensitive, rosacea-prone, or dry skin. Resilient, oily, or combination skin is the better fit.

How often should I use the Rejuran Pore Ampoule?

Use it at night a few times a week, not daily, applying a thin layer to pore-prone areas. Avoid pairing it with retinoids or other exfoliants the same night, follow with a moisturizer, and wear sunscreen every day, since both the acids and citrus oils increase sun sensitivity.

Should I choose the Rejuran pore ampoule or the pore pad?

The pad is fragrance-free and gentler for regular use, while this leave-on ampoule is more potent and targeted but adds citrus and lavender oils. If your skin is resilient and you want stronger, spot-focused pore care, the ampoule fits; for a gentler, fragrance-free routine, the pad is the safer pick.

Reviews

What shoppers tend to say

Recurring themes our editors read across retailer reviews — summaries in our words, not quotations, and not a substitute for a patch test.

Common praise

  • Visibly smoother, less shiny skin
  • Strong multi-acid pore and texture action
  • Niacinamide adds brightening
  • Targeted leave-on format

Common complaints

  • Contains bergamot, grapefruit, and lavender oils
  • Can be irritating with five acids plus witch hazel
  • Photosensitizing, demands strict sunscreen
  • Not for sensitive or dry skin
Notable endorsementsLeave-on pore ampoule from PDRN maker PharmaResearch's skincare armMulti-acid pore treatment with polynucleotide
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