The science
The one ingredient in this serum with a mechanistic case for the scalp is caffeine, and its evidence is worth stating precisely. A 2007 study in the International Journal of Dermatology cultured human hair follicles from men with androgenetic alopecia and found that testosterone suppressed hair shaft elongation while caffeine counteracted that suppression and, alone, stimulated growth, and a 2014 study in the British Journal of Dermatology extended the work to male and female follicles, showing caffeine prolonged anagen, promoted matrix and outer root sheath keratinocyte proliferation and shifted the balance of growth factors, with effects that differed between sexes. Caffeine is also known to penetrate the scalp and reach the follicle from a leave-on within minutes, so a daily serum with caffeine sixth on the list is a rational way to apply it. What the literature does not contain is a controlled trial showing that a cosmetic caffeine serum increases hair count or reduces shedding in people; the small studies that exist are cosmetic and uncontrolled, and the treatments with that evidence are topical minoxidil and oral finasteride. Alcohol denat. and menthol are the sensory base: alcohol evaporates fast, carries actives into the scalp and dries it with repeated use, and menthol activates the TRPM8 cold receptor for a cooling sensation that has no bearing on growth. The spicule claim fails on position: silica at seventeenth and diatomaceous earth at thirty-fifth can provide a gentle physical exfoliation when brushed through the scalp, but the micro-channel effect documented for sponge and silica spicules in laboratory skin-delivery work depends on concentrations that this serum does not carry. EGCG has in-vitro data on follicle cells and 5-alpha-reductase at defined concentrations and is at twenty-second here as a supporting note. Polydeoxyribonucleotide's regenerative evidence, as a 2026 systematic review of randomised trials in Cureus set out, belongs to injected and wound-dressing forms; sodium DNA at thirty-eighth in a scalp gel has no scalp study behind it. The fragrance, 4-terpineol, menthol and propolis are the ingredients with documented allergenic potential in a daily leave-on. Nothing has been published on this serum, and the assessment applies the caffeine and scalp-leave-on literature to a disclosed list.
References 3 ShowHide
- Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro — International Journal of Dermatology (2007)
- Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro — British Journal of Dermatology (2014)
- Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials — Cureus (2026)