The science
This balm's active ingredient, colloidal oatmeal at one percent, carries FDA skin protectant status based on the 2003 Final Monograph, which recognized oatmeal's efficacy for protecting and soothing minor skin irritation and itching due to eczema. A 2017 study by Lisante et al. demonstrated that a one percent colloidal oatmeal cream reduced Eczema Area and Severity Index (EASI) scores by 51% and Atopic Dermatitis Severity Index (ADSI) scores by 54% at 14 days in patients with mild to moderate atopic dermatitis.
Capone et al. published a 2020 study in the Journal of Drugs in Dermatology examining how colloidal oatmeal formulations affect both the skin barrier and the skin microbiome. The study found significant improvements in transepidermal water loss, skin hydration, and skin pH at day 14, along with beneficial shifts in the skin microbiome — a finding relevant to eczema, where Staphylococcus aureus overgrowth drives flare severity.
A 2023 study specifically evaluated one percent colloidal oatmeal cream in Black and African American children with mild to moderate atopic dermatitis, demonstrating clinical efficacy in a population historically underrepresented in dermatological research.
The ceramide NP component addresses a well-documented pathological feature of eczema: ceramide deficiency in the stratum corneum. Eczema patients show reduced levels of ceramides, particularly ceramide NP and ceramide AP, in affected skin. Topical ceramide supplementation has been shown to improve barrier function and reduce transepidermal water loss. The formula's oat kernel oil adds a second layer of ceramide support by activating the peroxisome proliferator-activated receptor (PPAR) pathway, which upregulates endogenous ceramide synthesis in keratinocytes — a pharmacologically distinct mechanism from direct ceramide supplementation.
Criado et al. published a 2020 double-blind study in Clinical, Cosmetic and Investigational Dermatology evaluating one percent colloidal oatmeal as add-on therapy for chronic irritant hand eczema, demonstrating benefit even as a supplementary treatment alongside existing therapy.
References 4 ShowHide
- A 1% Colloidal Oatmeal Cream Alone is Effective in Reducing Symptoms of Mild to Moderate Atopic Dermatitis: Results from Two Clinical Studies. — Journal of Drugs in Dermatology (2017)
- Effects of Colloidal Oatmeal Topical Atopic Dermatitis Cream on Skin Microbiome and Skin Barrier Properties. — Journal of Drugs in Dermatology (2020)
- The Efficacy of Colloidal Oatmeal Cream 1% as Add-on Therapy in the Management of Chronic Irritant Hand Eczema: A Double-Blind Study. — Clinical, Cosmetic and Investigational Dermatology (2020)
- A 1% colloidal oatmeal OTC cream is clinically effective for the management of mild to moderate atopic dermatitis in Black or African American children. — Journal of Drugs in Dermatology (2023)