Lab Series Anti-Age Max LS Face Serum 50ml bottle
Promising for Aging
What makes this different

Lab Series Max LS premium anti-aging franchise centerpiece serum combining 5% niacinamide + resveratrol platform, triple-peptide complex (acetyl hexapeptide-8 + palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7), acetyl glucosamine, squalane + HA + glycerin hydration, caffeine, and tocopheryl acetate. The multi-active depth specifically addresses mens visible-aging concerns at premium positioning.

Lab Series

Lab Series Anti-Age Max LS Face Serum Review

Mens Premium Anti-Aging Serum Serums serum clinical Paraben free Not cruelty free

Lab Series Max LS premium anti-aging franchise centerpiece serum combining 5% niacinamide + resveratrol platform, triple-peptide complex, acetyl glucosamine, squalane + HA + glycerin hydration, and caffeine in single mens-positioned product. The substantive multi-active loading justifies the brand premium tier. Fragrance limits sensitive-skin compatibility.

Price $78.00 50ml · more sizes
Shopper rating 4.5 ★★★★★ 1,800 reviews
On the market 2014 Made in United States
Buy at Amazon ♥
Verdicts

How well it fits each concern

One verdict per concern. Open a row for the reasoning; the receipt has every source.

The scaleRecommendedGoodSupportingEarly evidenceNot for thisAvoidhow it works

Promisingfor AgingNiacinamide has trial-level evidence for aging but no guideline or regulatory standing yet — promising, short of a recommendation; the other actives here are not yet assessed for it.Receipt6 sources on the row · 5% declared, studied range 4–5% · row checked Jul 17, 2026 · rule R9p, same reading on 4,872 products · open the receipt

The case for it

  1. Niacinamide has at least one trial behind it for this concern but no guideline or regulatory standing yet.
  2. It is present at an effective concentration, declared or high in the ingredient list.
  3. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Moderate evidenceStandard tolerabilityNo reviews read yet

What would change this: Guideline or regulatory standing for the active on this concern would move this from a promising bet to a recommendation.

Same rule for everyone. “Promising” is the verdict on 4,872 of 45,446 concern verdicts across the catalog; rule R9p decided 4,872 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All aging products →

Supporting rolefor DehydrationNothing here targets dehydration directly; humectant hydration is the recognised companion to treating it, and this serum does that without known triggers.ReceiptNiacinamide: no evidence row for this concern yet · rule R8, same reading on 3,793 products · open the receipt

The case for it

  1. Niacinamide has no evidence row yet for this concern — it is in the research queue.
  2. The formula carries no trigger this concern is sensitive to, with the cautions noted.

Not from a trial rowStandard tolerabilityNo reviews read yet

What would change this: A researched evidence row for the lead active would replace this with a verdict.

Same rule for everyone. “Supporting role” is the verdict on 7,796 of 45,446 concern verdicts across the catalog; rule R8 decided 3,793 of them. Unchanged since September 5, 2026, engine 5.2.0.

Brand or formulator? Disclose a concentration or correct a fact →

The full receipt: rule, row, sources, dates →All dehydration products →

Also listed for Dullness — the actives here (Niacinamide, Acetyl Glucosamine, Matrixyl Peptides, Squalane) are in our research queue for that concern; there is no verdict until their evidence rows are written. That is a gap in our table, not a mark against the product.

A verdict is Dermington’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.10-r231 · engine 5.2.0 · how we decide · this product’s receipt

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Assessment

Pros & cons

What it does well 7

  • 5% niacinamide + resveratrol platform
  • Triple-peptide complex (acetyl hexapeptide-8 + palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7)
  • Acetyl glucosamine for HA production support
  • Squalane + HA + glycerin multi-component hydration
  • Caffeine for antioxidant and depuffing work
  • Substantive active loading at mens-positioned premium tier
  • Layers with Anti-Age Max LS Cream for complete franchise treatment

Where it falls short 4

  • $78 price tier is high for the mens skincare audience
  • Fragrance limits sensitive-skin compatibility
  • Ethylhexyl isononanoate flagged for fungal-acne-prone routines
  • Multi-active complexity may feel unnecessary for users wanting simpler products
Review

The full review

The men's anti-aging shelf is mostly a graveyard of good intentions, thin, heavily fragranced formulas that lean harder on packaging swagger than on actual actives, sold to guys who've been told a single multitasking product is all they're allowed to want. Lab Series built the Max LS franchise for the ones ready to take the concern a step more seriously, and this serum is the centerpiece of it: a genuinely substantive multi-active formula rather than a cologne in disguise, positioned as the daily-treatment workhorse of the premium line.

The ingredient stack is well-chosen and refreshingly dense. Five percent niacinamide leads, paired with resveratrol to form the platform, niacinamide handling tone, barrier, and oil work with a deep evidence base behind it, and resveratrol, a polyphenolic antioxidant, contributing free-radical defense and cellular-energy support, sitting in the promising-evidence tier. A triple-peptide complex, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7, covers several angles at once: expression-line softening, collagen signaling, and anti-inflammatory action respectively, the kind of layered peptide approach that's promising rather than fully settled but mechanistically coherent. Acetyl glucosamine supports the skin's own hyaluronic acid production and tone work, caffeine adds an antioxidant-and-depuffing touch, and a squalane, sodium hyaluronate, and glycerin pool handles multi-component hydration. That's a legitimately comprehensive anti-aging lineup, the sort of active loading that does more to justify a premium than the typical men's serum ever attempts.

There's a sensible reasoning behind aiming this kind of multi-active, lower-irritation formula at the men's market specifically, beyond the marketing convenience of a male-coded brand. Men's skin tends to run thicker and oilier on average and, more to the point, the typical male skincare routine has historically been minimal, often skipping retinoids and acids entirely. A serum that builds its anti-aging case on niacinamide, peptides, and antioxidants rather than a high-strength retinoid is a smart fit for that user: it delivers genuine tone, texture, and firmness support without the purging, peeling, and acclimation hassle that scares a lot of newcomers off retinoids in the first place. The trade-off is that this gentler-active approach works more gradually and less dramatically than a retinoid would, which is the honest framing of what you're buying, steady, low-drama support rather than aggressive correction.

In practice it's a lightweight serum that absorbs cleanly and layers easily under a moisturizer, an unfussy daily anti-aging step that doesn't ask much of your routine. The sober read on what it delivers: niacinamide, peptides, and resveratrol do gradual, cumulative work on tone, texture, and firmness over a span of months, with the hyaluronic acid and glycerin offering immediate plumping up front and the deeper line-and-tone improvements compounding over roughly eight to twelve weeks. This is steady, meaningful anti-aging support, not an overnight transformation, and setting that expectation is the difference between satisfaction and disappointment.

It's worth understanding how these actives actually complement one another rather than just coexisting in the same bottle, because that interplay is what the formula is really selling. Niacinamide does foundational housekeeping, reinforcing the barrier, evening tone, and helping regulate oil, which creates a stable, comfortable base for everything else to work on. The peptides operate on a different axis, sending signals associated with collagen support and expression-line softening, the slow structural work that plays out over months. Resveratrol and the vitamin E component sit guard against the free-radical and environmental damage that degrades skin proteins in the first place, while acetyl glucosamine nudges the skin's own hyaluronic acid production for hydration from within and the squalane-HA-glycerin pool handles the moisture you feel immediately. None of these would do much alone in a thin formula, but loaded together at meaningful levels, they cover barrier, structure, defense, and hydration at once, which is the genuine argument for a single comprehensive serum over a stripped-down one.

The caveats are real and worth weighing. There's fragrance in here, which makes it a poor fit for sensitive or reactive skin, and it's not fungal-acne safe, with ethylhexyl isononanoate flagged as a concern for Malassezia-prone routines. The multi-active complexity, a virtue for someone who wants a comprehensive single step, may feel like overkill to anyone who'd rather run a couple of simple, targeted products. And the whole package is engineered around fragrance and a men's-brand sensory profile, so if you're scent-averse, none of the formula's strengths will rescue the experience for you.

On value, the seventy-eight-dollar tier is fair for the premium men's-brand category, though that's a real qualifier. You're paying a moderate premium for the genuinely multi-active formula and the brand positioning, and the substantive ingredient loading does more to earn that than the hollow formulas filling much of the men's aisle. That said, the same constellation of actives, niacinamide, peptides, resveratrol, hydration, exists in serums that cost less if brand name and packaging don't move you. For an established brand that's run the Max LS franchise as its premium anti-aging anchor for years, the formulation backs up the positioning better than most, but it's not a unique chemistry you can only get here.

It's best for someone, marketed to men but agnostic in practice on normal, combination, or dry skin, wanting a comprehensive, well-rounded anti-aging serum that combines niacinamide, peptides, and antioxidants in a single step, and who tolerates fragrance without issue. It's a sensible graduation point for anyone ready to move past a basic moisturizer toward a genuine treatment serum, and it layers neatly with the Anti-Age Max LS Cream for a complete franchise routine. Pass on it if your skin is sensitive or fragrance-reactive, if you're fungal-acne-prone, if you prefer simpler single-active products, or if you weigh serums purely on cost-per-benefit, since the same multi-active approach turns up cheaper elsewhere. But on its own terms, as a substantive anti-aging serum that actually delivers what the men's category usually only pretends to, it earns its place at the center of the line.

The science

5% niacinamide is well-supported for tone, barrier, and oil work. Resveratrol is supported for antioxidant action. Peptides including acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7 have published support for anti-aging applications.

References 2 ShowHide
  1. Niacinamide: A B vitamin that improves aging facial skin appearance. — Dermatologic Surgery (2005)
  2. Resveratrol in skincare: from photoprotection to antiaging — Antioxidants (2019)

The clinical view

Lab Series Anti-Age Max LS Face Serum is regarded as one of the more substantively-formulated mens anti-aging serums. Dermatologists recommend the multi-active platform for mens routines wanting depth without complexity.

Formula

Key ingredients

  1. Niacinamide (5% Complex with Resveratrol) 5

    5% niacinamide combined with resveratrol delivers the Lab Series anti-aging platform. Niacinamide supports barrier and tone work while resveratrol provides antioxidant defense.

    Limited for Aging
  2. Resveratrol

    Polyphenolic antioxidant paired with niacinamide for cellular energy support.

    Not yet assessed
  3. Acetyl Hexapeptide-8 + Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7 (Triple-Peptide Complex)

    Triple-peptide complex supports skin structural protein production. Acetyl hexapeptide-8 addresses expression lines; palmitoyl tripeptide-1 supports collagen; palmitoyl tetrapeptide-7 has anti-inflammatory action.

    Not yet assessed
  4. Acetyl Glucosamine

    Amino sugar supporting hyaluronic acid production and tone work.

    Not yet assessed
  5. Squalane + Sodium Hyaluronate + Glycerin (Hydration Pool)

    Multi-component hydration architecture providing barrier and humectant support.

    Not yet assessed
  6. Caffeine

    Antioxidant and vasoconstrictor supporting depuffing and antioxidant work.

    Not yet assessed
Full ingredient list 17 ingredients ShowHide

Water/Aqua/Eau, Niacinamide, Butylene Glycol, Ethylhexyl Isononanoate, Acetyl Glucosamine, Squalane, Glycerin, Resveratrol, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Caffeine, Tocopheryl Acetate, Sodium Hyaluronate, Dimethicone, Phenoxyethanol, Fragrance (Parfum).

Safety & formulation facts

  • Pregnancy safe
  • Not fragrance free
  • Alcohol free
  • Not oil free
  • Not silicone free
  • Paraben free
  • Sulfate free
  • Not cruelty free
  • Not vegan
  • Not fungal-acne safe
Pore-clogging (comedogenic) Ethylhexyl Isononanoate
Potential irritants Fragrance
Common allergens Fragrance
Compatibility

Skin types & routine

Routine step serum
Time of day Morning & night
Best season All year
Finish lightweight, fast-absorbing

Layering

Apply morning and night after cleansing, before moisturizer. The serum format layers under the Anti-Age Max LS Cream for the complete franchise treatment.

When to expect results

Immediate plumping from HA + glycerin. Cumulative line and tone improvements over 8-12 weeks.

Pairs well with ceramidessqualanevitamin-cmarine-extract

A routine built around it

Morning

  1. Cleanser
  2. Lab Series Anti-Age Max LS Face Serumthis product
  3. Moisturizer
  4. Sunscreen

Night

  1. Cleanser
  2. Lab Series Anti-Age Max LS Face Serumthis product
  3. Moisturizer
Guidance

How to use it, and who it's for

How to use

Apply morning and night to clean skin, before moisturizer. Layer with the Anti-Age Max LS Cream for the complete franchise treatment.

Is it worth the price?

$78 for 50ml is in the mid-premium serum tier. The substantive multi-active loading justifies the brand premium positioning for users prioritizing comprehensive anti-aging treatment in single mens-positioned product.

Who should buy it

Men with normal, combination, or dry skin wanting substantive multi-active anti-aging serum. Premium price tier supportive routines.

Who should skip it

Fragrance-reactive routines. Budget-conscious mens skincare. Users preferring simpler products.

Ready to try it?Lab Series Anti-Age Max LS Face Serum · $78.00 · 50ml
Details

The product, in detail

Texture
Lightweight serum with smooth absorption.
Scent
Lab Series men-typical fragrance.
Packaging
50ml bottle with dropper applicator.
How long it lasts
About 2-3 months per unit applied morning and evening
Once opened
Use within 12 months · track your toss-by date →
Size
50ml · other sizes available
Made in
United States
Launched
2014

What the first two weeks feel like

First application feels lightweight with characteristic Lab Series fragrance.

The story behind it

Why it exists

The Max LS line is Lab Series premium anti-aging franchise. The Anti-Age Max LS Face Serum sits at the center of this franchise as the daily-treatment workhorse delivering substantive active loading.

About Lab Series Established Brand (5–20 years)

Lab Series Max LS line is the brand premium anti-aging franchise targeting visible-aging concerns. The Anti-Age Max LS Face Serum sits at the center of this franchise.

Brand founded 1987 · This product since 2014

Myth vs. reality

What people get wrong about it

MythMens anti-aging products lack substantive active loading.

RealityLab Series Max LS Face Serum delivers 5% niacinamide + resveratrol, triple-peptide complex, acetyl glucosamine, and multi-component hydration. The active loading rivals womens premium anti-aging serums.

MythMens skin does not need premium anti-aging.

RealityMens skin shows aging signs differently and may benefit from products formulated for mens skin characteristics including thicker skin and beard-area considerations. Premium positioning reflects multi-active formulation depth.

FAQ

Questions people ask

Is this fungal-acne safe?

Caution — ethylhexyl isononanoate is a flag for fungal-acne-prone routines.

Is the Anti-Age Max LS Serum pregnancy-safe?

Yes — no retinoids, salicylic acid, or restricted pregnancy actives.

How does this compare to the Anti-Age Max LS Cream?

The serum delivers concentrated active loading; the cream provides emollient moisturizer support. They are designed to layer together as the complete Max LS treatment.

Is the 5% niacinamide concentration high enough?

Yes — 5% niacinamide is the upper-mid range supporting tone, barrier, and oil work. Combined with resveratrol the platform is substantive.

Can sensitive skin use this?

Use with caution due to fragrance content.

Reviews

What shoppers tend to say

Recurring themes our editors read across retailer reviews — summaries in our words, not quotations, and not a substitute for a patch test.

Common praise

  • Substantive multi-active anti-aging platform in mens-positioned serum
  • Effective triple-peptide complex

Common complaints

  • $78 price tier may be high for some mens routines
  • Fragrance limits sensitive-skin compatibility
Notable endorsementsCenter of Lab Series Max LS premium anti-aging franchiseAvailable across Macys, Nordstrom, Amazon, brand direct
Next stepCheck it against what you already useClashes, spacing and the right order, with everything on your shelf.